Version 1
: Received: 15 December 2023 / Approved: 17 December 2023 / Online: 18 December 2023 (07:03:58 CET)
How to cite:
Surguchov, A.; Surguchev, A. Association of Parkinson’s Disease and Cancer: New Findings and Possible Mediators. Preprints2023, 2023121258. https://doi.org/10.20944/preprints202312.1258.v1
Surguchov, A.; Surguchev, A. Association of Parkinson’s Disease and Cancer: New Findings and Possible Mediators. Preprints 2023, 2023121258. https://doi.org/10.20944/preprints202312.1258.v1
Surguchov, A.; Surguchev, A. Association of Parkinson’s Disease and Cancer: New Findings and Possible Mediators. Preprints2023, 2023121258. https://doi.org/10.20944/preprints202312.1258.v1
APA Style
Surguchov, A., & Surguchev, A. (2023). Association of Parkinson’s Disease and Cancer: New Findings and Possible Mediators. Preprints. https://doi.org/10.20944/preprints202312.1258.v1
Chicago/Turabian Style
Surguchov, A. and Alexei Surguchev. 2023 "Association of Parkinson’s Disease and Cancer: New Findings and Possible Mediators" Preprints. https://doi.org/10.20944/preprints202312.1258.v1
Abstract
Epidemiological evidence points to an inverse association between Parkinson's disease (PD) and almost all cancers except melanoma, for which this association is positive. The results of many studies have found that patients with PD are at reduced risk of the majority of neoplasm occurrence and death. Several potential biological explanations exist for the inverse relationship between cancer and PD. Recent results identified several PD-associated proteins and factors mediating cancer development and cancer-associated factors affecting PD. Accumulating data points to the role of genetic traits, members of the synuclein family, neurotrophic factors, ubiquitin-proteasome system, circulating melatonin, and transcription factors as such mediators. We present recent data about shared pathogenetic factors and mediators that might be involved in the association between these two diseases. We also discuss how these factors, individually or in combination, may be involved in pathology, serve as links between PD and cancer, and affect the prevalence of these disorders. Identification of these factors and investigations of their mechanisms will lead to the discovery of new targets for the treatment of both diseases
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
