Version 1
: Received: 13 December 2023 / Approved: 14 December 2023 / Online: 14 December 2023 (10:46:15 CET)
How to cite:
Rendine, M.; Cocci, P.; Vivo, L.D.; Bellesi, M.; Palermo, F.A. Effects of Chronic Sleep-Restriction on Transcriptional Regulation of SIRT1 Signaling in Mice White Adipose Tissue. Preprints2023, 2023121077. https://doi.org/10.20944/preprints202312.1077.v1
Rendine, M.; Cocci, P.; Vivo, L.D.; Bellesi, M.; Palermo, F.A. Effects of Chronic Sleep-Restriction on Transcriptional Regulation of SIRT1 Signaling in Mice White Adipose Tissue. Preprints 2023, 2023121077. https://doi.org/10.20944/preprints202312.1077.v1
Rendine, M.; Cocci, P.; Vivo, L.D.; Bellesi, M.; Palermo, F.A. Effects of Chronic Sleep-Restriction on Transcriptional Regulation of SIRT1 Signaling in Mice White Adipose Tissue. Preprints2023, 2023121077. https://doi.org/10.20944/preprints202312.1077.v1
APA Style
Rendine, M., Cocci, P., Vivo, L.D., Bellesi, M., & Palermo, F.A. (2023). Effects of Chronic Sleep-Restriction on Transcriptional Regulation of SIRT1 Signaling in Mice White Adipose Tissue. Preprints. https://doi.org/10.20944/preprints202312.1077.v1
Chicago/Turabian Style
Rendine, M., Michele Bellesi and Francesco Alessandro Palermo. 2023 "Effects of Chronic Sleep-Restriction on Transcriptional Regulation of SIRT1 Signaling in Mice White Adipose Tissue" Preprints. https://doi.org/10.20944/preprints202312.1077.v1
Abstract
A rather large portion of the population is sleep restricted in modern society, either by necessity or by choice. Epidemiological studies have observed that lack of sleep and poor sleep quality are associated with several pathological states, ranging from neuropsychiatric to metabolic diseases. To date, only a few studies have investigated the molecular consequences of sleep loss at the level of peripheral organs involved in maintaining metabolic homeostasis such as the white adipose tissue (WAT). From a molecular point of view, two key transcriptional regulators of WAT function are sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptors gamma (PPARγ). Both genes interact with specific targets involved in multiple metabolic processes, including adipocyte differentiation, browning and lipid metabolism. In this study, we assessed the effects of chronic sleep restriction (CSR) on the interplay between SIRT1 and PPARγ in mediating WAT metabolism in young adult mice. We found that CSR up-regulated expression of SIRT1 and some of its transcriptional targets involved in lipid metabolism and mitochondrial functions of adipocytes. Results suggest that CSR induces SIRT1-mediated metabolic remodeling of WAT to support an increased energy demand due to sleep loss.
Keywords
sleep deprivation; adipose tissue; mouse; qPCR
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
