Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Repurpose of Cellular Proteins during Enterovirus A71 Infection

Sudeshi M Abedeera
ORCID logo ,
Jesse Davila-Calderon
,
Christina Haddad
,
Barrington Henry
,
Josephine King
,
Srinivasa Penumutchu
,
Blanton S Tolbert
*
Version 1 : Received: 11 December 2023 / Approved: 12 December 2023 / Online: 12 December 2023 (07:13:23 CET)

A peer-reviewed article of this Preprint also exists.

Abedeera, S.M.; Davila-Calderon, J.; Haddad, C.; Henry, B.; King, J.; Penumutchu, S.; Tolbert, B.S. The Repurposing of Cellular Proteins during Enterovirus A71 Infection. Viruses 2024, 16, 75. Abedeera, S.M.; Davila-Calderon, J.; Haddad, C.; Henry, B.; King, J.; Penumutchu, S.; Tolbert, B.S. The Repurposing of Cellular Proteins during Enterovirus A71 Infection. Viruses 2024, 16, 75.

Abstract

Viruses pose a great threat to people’s lives. Enterovirus A71 (EV-A71) infects children and infants all over the world with no FDA-approved treatment to date. Understanding the basic mechanisms of viral processes aids in selecting more efficient drug targets and designing more effective antivirals to thwart this virus. The 5´-untranslated region (5’-UTR) of the viral RNA genome is composed of a cloverleaf structure and an internal ribosome entry site (IRES). Cellular proteins that bind to the cloverleaf structure regulate viral replication, while those that bind to the IRES also known as IRES trans-acting factors (ITAFs) regulate viral translation. In this review, we survey the cellular proteins currently known to bind the 5’-UTR and influence viral translation and replication with emphasis on comparing proteins’ functions and localizations pre- and post-(EV-A71) infection. Comprehensive understanding of how the host cell’s machinery is hijacked and reprogrammed by the virus to facilitate its replication is crucial for developing effective antivirals.

Keywords

Enterovirus A71 (EV-A71); ITAF; IRES; 5’-UTR

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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