Perrotta, F.; Piscopiello, D.; Rizzo, D.; Iosa, G.; Garzya, G.; Calò, P.; Gemma, D. Cytomegalovirus Pneumonia in a Patient with Down Syndrome. Medicina2024, 60, 242.
Perrotta, F.; Piscopiello, D.; Rizzo, D.; Iosa, G.; Garzya, G.; Calò, P.; Gemma, D. Cytomegalovirus Pneumonia in a Patient with Down Syndrome. Medicina 2024, 60, 242.
Perrotta, F.; Piscopiello, D.; Rizzo, D.; Iosa, G.; Garzya, G.; Calò, P.; Gemma, D. Cytomegalovirus Pneumonia in a Patient with Down Syndrome. Medicina2024, 60, 242.
Perrotta, F.; Piscopiello, D.; Rizzo, D.; Iosa, G.; Garzya, G.; Calò, P.; Gemma, D. Cytomegalovirus Pneumonia in a Patient with Down Syndrome. Medicina 2024, 60, 242.
Abstract
Down Syndrome (DS) is a chromosomal disorder due to the presence of an additional chromosome 21 that causes intellectual deficit and physical anomalies and predisposes patients to develop infections throughout their lives. Pneumonias are more serious in patients with DS, requiring hospitalization, and represent an important cause of mortality in this population. Cytomegalovirus (CMV) causes widespread and serious infections in immunocompromised individuals, affecting the respiratory tract and, causing interstitial pneumonia, is associated with a high mortality rate.
However, CMV-induced pneumonia is not reported in DS patients. The prevalence and severity of CMV respiratory infections in subjects with DS is unknown. This case describes a 50-year-old female patient suffering from DS who developed extensive bilateral pneumonia with severe respiratory failure which required hospitalization in intensive care, intubation and mechanical ventilation after approximately 10 days of empiric antibiotic and anitimycotic therapy for fever, cough and dyspnea. The patient was diagnosed with CMV pneumonia and recovered after treatment with Ganciclovir. To the best of our knowledge, this is the first reported case of CMV pneumonia in a patient with DS. This case aims to highlight that CMV pneumonia in individuals with DS can be a life-threatening condition. It also clarifies the importance of early diagnosis of infections from opportunistic pathogens such as CMV to ensure timely and efficient treatment.
Keywords
Down Syndrome; Pneumonia; Cytomegalovirus
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
