PreprintConcept PaperVersion 1Preserved in Portico This version is not peer-reviewed
Multiple Sclerosis Treatment Strategy Optimization by PREdicting DIsease Progression through Linear and Non-linear Dynamics of Eeg Time-Series: The “MuST Predict” Conceptual Framework
Version 1
: Received: 5 December 2023 / Approved: 6 December 2023 / Online: 6 December 2023 (10:33:52 CET)
How to cite:
Tseriotis, V. Multiple Sclerosis Treatment Strategy Optimization by PREdicting DIsease Progression through Linear and Non-linear Dynamics of Eeg Time-Series: The “MuST Predict” Conceptual Framework. Preprints2023, 2023120374. https://doi.org/10.20944/preprints202312.0374.v1
Tseriotis, V. Multiple Sclerosis Treatment Strategy Optimization by PREdicting DIsease Progression through Linear and Non-linear Dynamics of Eeg Time-Series: The “MuST Predict” Conceptual Framework. Preprints 2023, 2023120374. https://doi.org/10.20944/preprints202312.0374.v1
Tseriotis, V. Multiple Sclerosis Treatment Strategy Optimization by PREdicting DIsease Progression through Linear and Non-linear Dynamics of Eeg Time-Series: The “MuST Predict” Conceptual Framework. Preprints2023, 2023120374. https://doi.org/10.20944/preprints202312.0374.v1
APA Style
Tseriotis, V. (2023). Multiple Sclerosis Treatment Strategy Optimization by PREdicting DIsease Progression through Linear and Non-linear Dynamics of Eeg Time-Series: The “MuST Predict” Conceptual Framework. Preprints. https://doi.org/10.20944/preprints202312.0374.v1
Chicago/Turabian Style
Tseriotis, V. 2023 "Multiple Sclerosis Treatment Strategy Optimization by PREdicting DIsease Progression through Linear and Non-linear Dynamics of Eeg Time-Series: The “MuST Predict” Conceptual Framework" Preprints. https://doi.org/10.20944/preprints202312.0374.v1
Abstract
Gradual disability worsening in Multiple Sclerosis (MS) is indicative of confirmed progression that mostly involves progression independent of relapse activity (PIRA) and is associated with neurodegeneration. Insights from pathology reveal grey matter involvement (neocortex, hippocampus, spinal cord, and deep grey matter structures) and microglia activation in early stages of MS. Cortical lesions result in thinning and atrophy and are considered accurate predictors of disability progression and cognitive decline.Neuroimaging biomarkers, such as high-resolution 7T MR images and TSPO-PET, have been examined for the detection of cortical pathology linked to cognitive deficits and thus progression, but are limited in clinical practice due to availability, time constraints, and cost.Electroencephalography (EEG) emerges as a non-invasive, cost-effective tool that reflects cortical activity in MS. Its potential in monitoring cognitive impairment is explored by focusing on nonlinear EEG analysis. The MuST PREDICTTM project aims to extract linear and nonlinear EEG features, investigating their role in predicting disease progression and optimizing treatment. The study employs retrospective, cross-sectional, and prospective designs, utilizing EEGs from various MS forms, cognitive assessments, serum/cerebrospinal fluid biomarkers and neuroimaging. The methodology involves time-based and spectral feature extraction, employing artificial intelligence classifiers and brain criticality-based approaches.The conceptual framework of an innovative modality is herein presented, that would EEG for early MS progression detection. Standardization of the methodology could lead to the creation of a digital tool for better prognostication and treatment strategy optimization.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
