Version 1
: Received: 1 December 2023 / Approved: 4 December 2023 / Online: 4 December 2023 (11:27:16 CET)
How to cite:
Sacomboio, E.N.M.; Paulo, T.P.P.; Cassinela, E.K.; Sebastião, C.D.S. Urinalysis Results and Resistance to Hospital Treatment with Injectable Antimalarials in Angola. Preprints2023, 2023120167. https://doi.org/10.20944/preprints202312.0167.v1
Sacomboio, E.N.M.; Paulo, T.P.P.; Cassinela, E.K.; Sebastião, C.D.S. Urinalysis Results and Resistance to Hospital Treatment with Injectable Antimalarials in Angola. Preprints 2023, 2023120167. https://doi.org/10.20944/preprints202312.0167.v1
Sacomboio, E.N.M.; Paulo, T.P.P.; Cassinela, E.K.; Sebastião, C.D.S. Urinalysis Results and Resistance to Hospital Treatment with Injectable Antimalarials in Angola. Preprints2023, 2023120167. https://doi.org/10.20944/preprints202312.0167.v1
APA Style
Sacomboio, E.N.M., Paulo, T.P.P., Cassinela, E.K., & Sebastião, C.D.S. (2023). Urinalysis Results and Resistance to Hospital Treatment with Injectable Antimalarials in Angola. Preprints. https://doi.org/10.20944/preprints202312.0167.v1
Chicago/Turabian Style
Sacomboio, E.N.M., Edson Kuatelela Cassinela and Cruz dos Santos Sebastião. 2023 "Urinalysis Results and Resistance to Hospital Treatment with Injectable Antimalarials in Angola" Preprints. https://doi.org/10.20944/preprints202312.0167.v1
Abstract
Background: Resistance to antimalarial drugs often used in emerging countries, including combination therapies, has forced scientists to search for and develop drugs with novel mechanisms of action, especially resistance to Plasmodium falciparum and Plasmodium vivax, which are highly prevalent in Southeast Asia, Africa, and South America.
Objective: evaluate whether there is a relationship between urinalysis and resistance to in-hospital treatment of malaria in Angola.
Methodology: This was a cross-sectional, prospective study with a quantitative approach.
Results: of the 214 patients, the resistance rate was 24.1%, men (53.6%), between 21 and 40 years old (72.7%), employees (46.4%), from peri-urban regions (77.7%), treated with artemether (90.9), with high parasitemia (57.7%) and after 5 days of treatment, remained hospitalized (61.4%). Was a significant relationship between resistance in unemployed individuals [OR: 0.03 (95% CI: 0.01-0.29), p =0.003] and high levels of parasitemia [OR: 1.09 (95% CI: 1.09-3.95), p=0.040], remained hospitalized for more than 5 days [OR: 5.28 (95% CI: 0.65-43.1), p=0.121] and death [OR: 2.59 (95% CI: 0.32-20.9), p=0.371] when compared with other subgroups. Was a significant relationship between resistance to clear urine [OR: 5.55 (95% CI: 0.72-42.7), p =0.016], few urinary crystals [OR: 11.3 (95% CI: 5.07-25.3), p <0.001] and who presented some microorganisms that were not bacteria or fungi [OR: 3.02 (95% CI: 1 .32-6.90), p=0.009].
Conclusion: urine results, especially the appearance of cloudy urine, the presence of few crystals, and the presence of other microorganisms that are not bacteria or fungi, may be clear signs of resistance to hospital treatment with injectable antimalarials.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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