Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities

Agnieszka Zakrzewska; Jan Biedunkiewicz; Michał Komorniczak; Magdalena Jankowska; Katarzyna Jasiulewicz; Natalia Płonka; Bogdan Biedunkiewicz; Sylwia Małgorzewicz; Agnieszka Tarasewicz; Ewelina Puchalska-Reglińska; Janusz Siebert; Alicja Dębska-Ślizień; Leszek Tylicki

doi:10.20944/preprints202311.2006.v2

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preprints.org > medicine and pharmacology > urology and nephrology > doi: 10.20944/preprints202311.2006.v2

Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities

Katarzyna Jasiulewicz

Ewelina Puchalska-Reglińska

Janusz Siebert

Alicja Dębska-Ślizień

Leszek Tylicki

Version 1 : Received: 30 November 2023 / Approved: 30 November 2023 / Online: 30 November 2023 (16:12:12 CET)
Version 2 : Received: 27 December 2023 / Approved: 28 December 2023 / Online: 28 December 2023 (12:51:02 CET)

A peer-reviewed article of this Preprint also exists.

Zakrzewska, A.; Biedunkiewicz, J.; Komorniczak, M.; Jankowska, M.; Jasiulewicz, K.; Płonka, N.; Biedunkiewicz, B.; Małgorzewicz, S.; Tarasewicz, A.; Puchalska-Reglińska, E.; Siebert, J.; Dębska-Ślizień, A.; Tylicki, L. Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities. J. Clin. Med. 2024, 13, 326. Zakrzewska, A.; Biedunkiewicz, J.; Komorniczak, M.; Jankowska, M.; Jasiulewicz, K.; Płonka, N.; Biedunkiewicz, B.; Małgorzewicz, S.; Tarasewicz, A.; Puchalska-Reglińska, E.; Siebert, J.; Dębska-Ślizień, A.; Tylicki, L. Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities. J. Clin. Med. 2024, 13, 326.

Abstract

There are several forms of maintenance high-efficiency hemodialysis (HD) including hemodiafiltrations (HDF) in different technic modes and expanded HD using dialyzers with medium cut-off membranes. The aim of the study was to assess the intradialytic tolerance and length of dialysis recovery time (DRT) in these modalities. This is an exploratory, cross-over study in maintenance HD patients with low comorbidity and no clinical indications for the use of high-efficiency HD, who were exposed to five intermittent dialysis in random order: high flux hemodialysis (S-HD), expanded HD (HDx), pre-dilution HDF (PRE-HDF), mix-dilution HDF (MIX-HDF) and post-dilution HDF (POST-HDF). 24 dialysis sessions of each method were included in the analysis. Dialysis parameters including blood flow rate, dialysis fluid flow rate and temperature, and pharmacological treatment were constant. Average total convection volume for post-HDF, pre-HDF and mix-HDF were 25.6 (3.8), 61.5 (7.2) and 47.1 (11.4) l, respectively. During all therapies, patients had similar hydration status monitored using bioimpedance spectroscopy and similar variability over time in systemic blood pressure, cardiac output, and peripheral resistance monitored using impedance cardiography. The lowest frequency of all intradialytic adverse events were observed during HDx. Delayed DRT was the shortest during PRE-HDF. Patients were also more likely to report immediate recovery while receiving PRE-HDF. These differences did not reach statistical significance, however the study results suggest that, intradialytic tolerance and DRT may depend on the dialysis method used. This support the need of taking into account patient preferences and quality of life while individualizing high efficiency therapy in HD patients.

Keywords

hemodialysis; hemodiafiltration; expanded hemodialysis; quality od life

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comment 1

Received: 28 December 2023
Commenter: Leszek Tylicki
Commenter's Conflict of Interests: Author

Comment: The first revision of the manuscript in accordance with the suggestions of JCM reviewers.

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