Pintos, G.B.; Pires, F.C.B.L.; Silva, R.C.M.A.; Silva Junior, F.I.M.; Zini, N.; Da Silva, R.F.; De Mattos, L.C.; Brandão, C.C. Toxoplasma gondii Infection in Patients Submitted to Liver Transplantation. Preprints2023, 2023111999. https://doi.org/10.20944/preprints202311.1999.v1
APA Style
Pintos, G.B., Pires, F.C.B.L., Silva, R.C.M.A., Silva Junior, F.I.M., Zini, N., Da Silva, R.F., De Mattos, L.C., & Brandão, C.C. (2023). Toxoplasma gondii Infection in Patients Submitted to Liver Transplantation. Preprints. https://doi.org/10.20944/preprints202311.1999.v1
Chicago/Turabian Style
Pintos, G.B., Luiz Carlos De Mattos and Cinara Cássia Brandão. 2023 "Toxoplasma gondii Infection in Patients Submitted to Liver Transplantation" Preprints. https://doi.org/10.20944/preprints202311.1999.v1
Abstract
Background: The liver has emerged as a frequent transplanted organ which can transmit T. gondii between seropositive donors and seronegative recipients. Associated with the immunosuppressive therapy of recipients, the presence of cysts in donor livers elevate the risk of severe toxoplasmosis in recipients. Objectives: The objective of the study was to verify the frequencies of positive serology in liver graft donors and their respective recipients, as well as to verify whether their clinical signs presented post-transplant are associated with the serological status of recipients. Patients and methods: All data on liver transplant recipients from 2008 to 2018 were obtained from the MVPeP electronic medical records of the Liver Transplant Service of FUNFARME/FAMERP. IgM and IgG anti-T. gondii antibody serology was investigated by chemiluminescence. According to the serological profile, four groups of recipients were assessed (G1: IgG-/IgM-; G2: IgG+/IgM-; G3: IgG+/IgM+, G4: IgG-/IgM+). Results: The numbers of recipients according to the serological profile groups were: G1: 20 (41.7%), G2: 26 (54.1%; G3: 2 (4.2%). No cases were found for G4. Post-transplant clinical manifestations such as fever without defined cause, lung nodules, headache, hepatosplenomegaly, encephalopathy and hepatitis (A, B and C) were reported in all groups. Conclusions: This study demonstrates that there is a high prevalence of T. gondii infection in liver recipients and, therefore, screening should be intensified. Furthermore, a high incidence of co-infection with hepatitis A was identified especially in patients who died in the post-transplant period.
Keywords
Toxoplasma gondii; solid organ transplantation; liver transplantation; infection
Subject
Medicine and Pharmacology, Transplantation
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
