Seedevi, P.; Ramasamy, P.; Mohan, R.; Batoo, K.M.; Hussain, S.; Vairamani, S.; Shanmugam, A. Sulfated Polysaccharide from Gracilaria edulis and its Structural Characterization: Protective Effect against CCl4-Induced Liver Injury. Preprints2023, 2023111605. https://doi.org/10.20944/preprints202311.1605.v1
APA Style
Seedevi, P., Ramasamy, P., Mohan, R., Batoo, K.M., Hussain, S., Vairamani, S., & Shanmugam, A. (2023). Sulfated Polysaccharide from <em>Gracilaria edulis</em> and its Structural Characterization: Protective Effect against CCl<sub>4</sub>-Induced Liver Injury. Preprints. https://doi.org/10.20944/preprints202311.1605.v1
Chicago/Turabian Style
Seedevi, P., Shanmugam Vairamani and Annaian Shanmugam. 2023 "Sulfated Polysaccharide from <em>Gracilaria edulis</em> and its Structural Characterization: Protective Effect against CCl<sub>4</sub>-Induced Liver Injury" Preprints. https://doi.org/10.20944/preprints202311.1605.v1
Abstract
The sulfated polysaccharide (SP) was extracted from Gracilaria edulis and tested for its ability to protect against carbon tetrachloride (CCl4)-induced liver injury in Wistar rats. The chemical composition of the sulfated polysaccharide, documented 12.90% of yield, 83.07% of carbohydrate, 0% of protein, 15.02% of ash, and 2.09% of moisture, and the carbon, hydrogen, nitrogen, and sulfur content were 25.90%, 4.28%, 2.65%, and 3.61%. SP has a molecular weight of 41kDa. The monosaccharide and structural properties of SP were investigated using GC-MS, FT-IR, and 1H-NMR spectral analysis. In rats, CCl4 produced hepatotoxicity, as evidenced by an increase in serum ALT, AST, and ALP levels and a decrease in ALB levels. The SP treated showed decreases in ALT, AST and ALP levels, as well as an increase in ALB levels. SOD, catalase, GPx, and GSH levels were suggestively lower in CCL4-induced rats compared to normal control rats. SOD, catalase, GPx and GSH levels in the SP-treated rats, on the other hand, improved to normal levels. The rat liver tissue treated with SP recovered well from hepatic injury. SP can be considered an alternative in the treatment of liver injury or as preventive medicine.
Keywords
Sulfated polysaccharide; G. edulis; Liver injury; Protective effect
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
