Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Relationships between Serum Biomarkers among Hepatocellular Carcinoma Patients in Bangladeshi Fishing Communities: A Model Study

Mr Tufael
* ,
Auditi kar
,
Vijay Jagdish Upadhye
* ORCID logo ,
Amith Dutta
,
Atiqur Rahman Sunny
* ORCID logo ,
Abdus Sattar
,
Md. Eunus Ali
,
Julakha Akter
,
Kaniz Fatima Bari
,
Md. Tahsin Salam
,
Palash Chandra Banik
ORCID logo ,
Md. Anower Hussain
Version 1 : Received: 21 November 2023 / Approved: 23 November 2023 / Online: 23 November 2023 (10:02:30 CET)

A peer-reviewed article of this Preprint also exists.

Tufael, Auditi Kar, Vijay Jagdish Upadhye et al., (2024). Serum Biomarkers' Significance and Gender-Specific Hepatocellular Carcinoma Insights of Fishers Patient in Bangladesh, Journal of Angiotherapy, 8(1), 1-9, 9440 Tufael, Auditi Kar, Vijay Jagdish Upadhye et al., (2024). Serum Biomarkers' Significance and Gender-Specific Hepatocellular Carcinoma Insights of Fishers Patient in Bangladesh, Journal of Angiotherapy, 8(1), 1-9, 9440

Abstract

The study explored the correlation between serum biomarkers and hepatocellular carcinoma detection in various fishing groups, utilizing a descriptive and experimental approach in Bangladesh. The study identified fishers often consume tobacco, polluted drinking water, and lack sufficient sunlight, all of which are extremely detrimental to their health. Fishermen who mostly fish at night and spend little time on the water during the daytime hours do not get enough sunlight, nor do they get enough vitamin D. An increased risk of liver cancer was found to be directly and strongly correlated with insufficient serum levels of vitamin D. In addition, a negligent lifestyle, a lack of awareness about hepatitis, and inadequate nutritional assistance have significantly increased their risk. Our results contribute to the information on HCC assessment and evaluation by clarifying the relevance of serum vitamin D, alpha-fetoprotein (AFP), creatinine (Cr), and hemoglobin A1C (HbA1c) in distinguishing between categories and sexes. According to the study, the combination of AFP, Vitamin-D, and Cr (AFP+Vit-D+Cr) has a high predictive value, which improves diagnosis and offers a reliable instrument for identifying liver cancer.

Keywords

serum biomarkers; hepatocellular carcinoma; fishers; Bangladesh

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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