PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Molecular Characterization of the Disruptive Effects by two Curcuminoids, Demethoxycurcumin and Bisdemethoxycurcu-min, on the Larval Development of Drosophila melanogaster
Jeon, J.-H.; Jeong, S.-A.; Park, D.-S.; Park, H.-H.; Shin, S.-W.; Oh, H.-W. Disruptive Effects of Two Curcuminoids (Demethoxycurcumin and Bisdemethoxycurcumin) on the Larval Development of Drosophila melanogaster. Insects2023, 14, 959.
Jeon, J.-H.; Jeong, S.-A.; Park, D.-S.; Park, H.-H.; Shin, S.-W.; Oh, H.-W. Disruptive Effects of Two Curcuminoids (Demethoxycurcumin and Bisdemethoxycurcumin) on the Larval Development of Drosophila melanogaster. Insects 2023, 14, 959.
Jeon, J.-H.; Jeong, S.-A.; Park, D.-S.; Park, H.-H.; Shin, S.-W.; Oh, H.-W. Disruptive Effects of Two Curcuminoids (Demethoxycurcumin and Bisdemethoxycurcumin) on the Larval Development of Drosophila melanogaster. Insects2023, 14, 959.
Jeon, J.-H.; Jeong, S.-A.; Park, D.-S.; Park, H.-H.; Shin, S.-W.; Oh, H.-W. Disruptive Effects of Two Curcuminoids (Demethoxycurcumin and Bisdemethoxycurcumin) on the Larval Development of Drosophila melanogaster. Insects 2023, 14, 959.
Abstract
Juvenile hormones (JH) play crucial roles in insect development, reproduction, and other physi-ological functions. Because JH is specific to arthropods, including insects, it has long been stud-ied for use in pest control. Accordingly, this study aimed to identify the substances that act as JH disruptors from edible plants. Curcuminoids generally exhibit a wide range of biological ac-tivities, such as antioxidant, anti-inflammatory, antibacterial, and insecticidal properties, and they exhibit insect growth inhibitory effects. Demethoxycurcumin and bisdemethoxycurcumin, two curcuminoids from the turmeric plant Curcuma longa L. inhibit the formation of a metho-prene-tolerant (Met)–Taiman (Tai) heterodimer complex as shown through in vitro yeast two-hybrid assays. An artificial diet containing 1% (w/v) demethoxycurcumin or bisdemethox-ycurcumin reduced the number of larvae, leading to no pupal development. Building on our re-sults regarding curcuminoids, researchers can use our study as a reference to develop eco-friendly pesticides.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
