Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

First Sero-Epidemiological Investigation of SARS-CoV-2 among Students and Staff of Polytechnic High School a Community of Cheikh Anta Diop University after the Fourth Wave of COVID-19 in Senegal

Fatou THIAM
* ORCID logo ,
Abou Abdallah Malick Diouara
ORCID logo ,
Clemence Stephanie Chloe Anoumba NDIAYE
,
Ibrahima DIOUF
ORCID logo ,
Khadim KEBE
,
Assane SENGHOR
,
Djibaba DJOUMOI
,
Mame Ndew MBAYE
,
Idy DIOP
,
Sarbanding SANE
,
Seynabou COUNDOUL
,
Sophie Deli Tene
,
Mamadou DIOP
,
Abdou Lahat Dieng
,
Mamadou NDIAYE
,
Massamba DIOUF
,
Saïdou Moustapha Sall
,
Cheikh Momar NGUER
Version 1 : Received: 21 November 2023 / Approved: 22 November 2023 / Online: 24 November 2023 (04:12:01 CET)

How to cite: THIAM, F.; Diouara, A.A.M.; NDIAYE, C.S.C.A.; DIOUF, I.; KEBE, K.; SENGHOR, A.; DJOUMOI, D.; MBAYE, M.N.; DIOP, I.; SANE, S.; COUNDOUL, S.; Tene, S.D.; DIOP, M.; Dieng, A.L.; NDIAYE, M.; DIOUF, M.; Sall, S.M.; NGUER, C.M. First Sero-Epidemiological Investigation of SARS-CoV-2 among Students and Staff of Polytechnic High School a Community of Cheikh Anta Diop University after the Fourth Wave of COVID-19 in Senegal. Preprints 2023, 2023111372. https://doi.org/10.20944/preprints202311.1372.v1 THIAM, F.; Diouara, A.A.M.; NDIAYE, C.S.C.A.; DIOUF, I.; KEBE, K.; SENGHOR, A.; DJOUMOI, D.; MBAYE, M.N.; DIOP, I.; SANE, S.; COUNDOUL, S.; Tene, S.D.; DIOP, M.; Dieng, A.L.; NDIAYE, M.; DIOUF, M.; Sall, S.M.; NGUER, C.M. First Sero-Epidemiological Investigation of SARS-CoV-2 among Students and Staff of Polytechnic High School a Community of Cheikh Anta Diop University after the Fourth Wave of COVID-19 in Senegal. Preprints 2023, 2023111372. https://doi.org/10.20944/preprints202311.1372.v1

Abstract

Cross-sectional survey was conducted to capture the true extent of COVID-19 exposure among students and staff of Polytechnic High School (PHS). Random cluster sampling was carried out between May 19 and August 18, 2022, after the fourth wave of COVID-19 transmission. IgM and IgG SARS-CoV-2 antibodies were screened using WANTAI SARS-CoV-2 ELISA assays. Seroprevalence and descriptive statistics were calculated. Moreo-ver, the association between seropositivity and different factors (age, gender, preventive measures comorbidity, and symptoms, etc.) was determined using Logistic Regression. The overall IgG and IgM seroprevalence were 92% and 6.91% respectively. We found a higher IgM seroprevalence in men than women (9.4% vs. 5.6%) and a lower IgM seroprevalence in (18-25) age group compared to (55-65) years. Low compliance with preventive measures was found with a significant IgM seroprevalence depending on non-respect of social distancing (p = 0.008). A total of 70% of participants presented symptoms linked to COVID-19 at the moment of the survey. Results revealed a significant difference according to IgG seroprevalence among participants who declared fa-tigue symptoms 92.06% compared to those who did not 80.39% (p = 0.0027). IgM seropositivity was associated with Body Mass Indice (BMI) categorized (O.R. 0.238, p = 0.043), ethnic group (O.R. 0.723, p = 0.046) and marital status (O.R. 2.399, p = 0.021). Moreover, IgG seropositivity was associated with Chronic sinusitis comorbidity (O.R. 0.238, p = 0.043) and vaccination status (O.R. 4.741, p < 0.001). The majority of students and staff have al-ready been exposed to SARS-CoV-2 and confirm the circulation of SARS-CoV-2 in PHS at the time of the survey. Our results underline the importance of sero-epidemiological surveys to estimate the real impact of the COVID-19 pandemic in a community and to monitor disparities in antibody response in the population.

Keywords

COVID-19; SARS-CoV-2 antibodies; sero-epidemiological survey; Polytechnic High School; Senegal

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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