Version 1
: Received: 14 November 2023 / Approved: 14 November 2023 / Online: 15 November 2023 (10:36:55 CET)
How to cite:
Yin, J.; Ni, D.; Li, R.; Xi, J.; Wei, C.; Zhang, Y. Causal Role of Immune Cells in Prostate Cancer: A Mendelian Randomization Study. Preprints2023, 2023110976. https://doi.org/10.20944/preprints202311.0976.v1
Yin, J.; Ni, D.; Li, R.; Xi, J.; Wei, C.; Zhang, Y. Causal Role of Immune Cells in Prostate Cancer: A Mendelian Randomization Study. Preprints 2023, 2023110976. https://doi.org/10.20944/preprints202311.0976.v1
Yin, J.; Ni, D.; Li, R.; Xi, J.; Wei, C.; Zhang, Y. Causal Role of Immune Cells in Prostate Cancer: A Mendelian Randomization Study. Preprints2023, 2023110976. https://doi.org/10.20944/preprints202311.0976.v1
APA Style
Yin, J., Ni, D., Li, R., Xi, J., Wei, C., & Zhang, Y. (2023). Causal Role of Immune Cells in Prostate Cancer: A Mendelian Randomization Study. Preprints. https://doi.org/10.20944/preprints202311.0976.v1
Chicago/Turabian Style
Yin, J., Can Wei and Yanbin Zhang. 2023 "Causal Role of Immune Cells in Prostate Cancer: A Mendelian Randomization Study" Preprints. https://doi.org/10.20944/preprints202311.0976.v1
Abstract
Background：Increasingly, epidemiological surveys and experimental research findings indicate the involvement of immune cells in the onset and progression of prostate cancer. However, it remains unclear whether the relationship between specific immune cell types and prostate cancer is causal or influenced by bias. Through a two-sample Mendelian randomization design, our study aims to uncover the association between different immune cells and the risk of prostate cancer.Methods：A comprehensive study was conducted to investigate the association between immunophenotypes and prostate cancer risk. The study included a total of 731 immunophenotypes as potential exposure factors and analyzed data from 182,625 individuals of European ancestry from the UK Biobank. A screening of 12,097,504 single nucleotide polymorphisms (SNPs) was performed. The main analysis utilized the two-sample Mendelian randomization method with inverse variance weighting (IVW). Additionally, multiple analysis methods were combined, and various tests were conducted to assess heterogeneity and pleiotropy.Results：The resulting study showed a causal relationship between a total of 34 immune phenotypes and prostate cancer. Among them, the four immune phenotypes of CD62L- DC AC, CD19 on sw mem, FSC-A on plasmacytoid DC and HLA DR on monocyte simultaneously meet three or more statistical methods, suggesting a significant causal relationship with prostate cancer. Additionally, among the 34 immunophenotypes, CD28-CD8dim AC was shown to be positive in reverse Mendelian randomization. Most of these cell phenotypes have been reported to be potentially associated with prostate cancer.Conclusions：Our study demonstrates a causal link between immune cells and prostate cancer risk. Filled in the possible roles of all current immune cell pathways in the development and progression of prostate cancer. The next step is to verify the content and influencing mechanism of these immune phenotypes in cancer cells and adjacent cells through experiments, so as to provide new ideas and methods for the prevention and treatment of prostate cancer.
Keywords
immune cells; prostate cancer; immunophenotype; mendelian randomization; two sample
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
