Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials

Gareth Zigui Lim; Jonathan Yexian Lai; Christopher Ying Hao Seet; Carol Huilian Tham; Narayanaswamy Venketasubramanian; Benjamin Yong Qiang Tan; Mingxue Jing; Joshua Yee Peng Yeo; May Zin Myint; Ching-Hui Sia; Hock Luen Teoh; Vijay Kumar Sharma; Bernard Chan; Cunli Yang; Andrew Makmur; Shao Jin Ong; Leonard Litt Yeo Leong

doi:10.20944/preprints202311.0808.v1

A peer-reviewed article of this Preprint also exists.

Lim, G.Z.; Lai, J.Y.; Seet, C.Y.H.; Tham, C.H.; Venketasubramanian, N.; Tan, B.Y.Q.; Jing, M.; Yeo, J.Y.P.; Myint, M.Z.; Sia, C.-H.; Teoh, H.L.; Sharma, V.K.; Chan, B.P.L.; Yang, C.; Makmur, A.; Ong, S.J.; Yeo, L.L.L. Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials. J. Cardiovasc. Dev. Dis. 2023, 10, 499. Lim, G.Z.; Lai, J.Y.; Seet, C.Y.H.; Tham, C.H.; Venketasubramanian, N.; Tan, B.Y.Q.; Jing, M.; Yeo, J.Y.P.; Myint, M.Z.; Sia, C.-H.; Teoh, H.L.; Sharma, V.K.; Chan, B.P.L.; Yang, C.; Makmur, A.; Ong, S.J.; Yeo, L.L.L. Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials. J. Cardiovasc. Dev. Dis. 2023, 10, 499.

Abstract

Endovascular therapy (EVT) has revolutionized the management of acute ischaemic strokes with large vessel occlusion, with emerging evidence suggesting its benefit also in large infarct core volume strokes. In the last 2 years, 4 randomised controlled trials have been published on this topic - RES-CUE-Japan-LIMIT, ANGEL-ASPECT, SELECT2 and TENSION, with overall results showing that EVT improves functional and neurological outcomes compared to medical management alone. This review seeks to summarise the recent evidence presented by these 4 trials and highlight some of the limitations of our current understanding on this topic.

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Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials

Abstract

Keywords

Subject

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