El Safadi, D.; Lebeau, G.; Turpin, J.; Lefebvre d’Hellencourt, C.; Diotel, N.; Viranaicken, W.; Krejbich-Trotot, P. The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression. Viruses2024, 16, 24.
El Safadi, D.; Lebeau, G.; Turpin, J.; Lefebvre d’Hellencourt, C.; Diotel, N.; Viranaicken, W.; Krejbich-Trotot, P. The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression. Viruses 2024, 16, 24.
El Safadi, D.; Lebeau, G.; Turpin, J.; Lefebvre d’Hellencourt, C.; Diotel, N.; Viranaicken, W.; Krejbich-Trotot, P. The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression. Viruses2024, 16, 24.
El Safadi, D.; Lebeau, G.; Turpin, J.; Lefebvre d’Hellencourt, C.; Diotel, N.; Viranaicken, W.; Krejbich-Trotot, P. The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression. Viruses 2024, 16, 24.
Abstract
Zika Virus (ZIKV) is a pathogenic member of the flavivirus family, with several unique charac-teristics. Unlike any other arbovirus, ZIKV can be transmitted sexually and maternally, and thus produce congenital syndromes (CZS) due to its neurotropism. This challenges the search for safe active molecules that can protect pregnant women and their fetuses. In this context, and in the ab-sence of any existing treatment, it seemed worthwhile to test whether the known cytoprotective properties of adiponectin and its pharmacological analog, AdipoRon, could influence the outcome of ZIKV infection. We showed that both AdipoRon and adiponectin could significantly reduce in vitro infection of A549 epithelial cells, a well-known cell model for flaviviruses infection studies. This effect was particularly observed when a pre-treatment was carried out. Conversely, ZIKV revealed an ability to down-regulate adiponectin receptor expression and thereby limit adi-ponectin signaling.
Keywords
Zika virus; antiviral; AdipoRon; adiponectin agonist; drug repositioning; metabolism
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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