Version 1
: Received: 8 November 2023 / Approved: 9 November 2023 / Online: 9 November 2023 (14:39:52 CET)
How to cite:
Soni, Z.; Vora, S.; Desai, D. Insights on Ferritin as a Screening and a Diagnostic Marker for Still’s Disease: A Narrative review. Preprints2023, 2023110649. https://doi.org/10.20944/preprints202311.0649.v1
Soni, Z.; Vora, S.; Desai, D. Insights on Ferritin as a Screening and a Diagnostic Marker for Still’s Disease: A Narrative review. Preprints 2023, 2023110649. https://doi.org/10.20944/preprints202311.0649.v1
Soni, Z.; Vora, S.; Desai, D. Insights on Ferritin as a Screening and a Diagnostic Marker for Still’s Disease: A Narrative review. Preprints2023, 2023110649. https://doi.org/10.20944/preprints202311.0649.v1
APA Style
Soni, Z., Vora, S., & Desai, D. (2023). Insights on Ferritin as a Screening and a Diagnostic Marker for Still’s Disease: A Narrative review. Preprints. https://doi.org/10.20944/preprints202311.0649.v1
Chicago/Turabian Style
Soni, Z., Samkit Vora and Dev Desai. 2023 "Insights on Ferritin as a Screening and a Diagnostic Marker for Still’s Disease: A Narrative review" Preprints. https://doi.org/10.20944/preprints202311.0649.v1
Abstract
Still’s disease, also known as systemic juvenile idiopathic arthritis, is an autoimmune disorder with a triad of fever, salmon pink rash, and inflammatory polyarthritis. Its diagnosis is quite challenging due to the lack of specific symptoms and overlap with many other rheumatological and autoimmune disorders. However, recent studies have shown that high serum ferritin levels can act as a biomarker for this disease. Ferritin is an intracellular iron storage protein that acts as a pro-inflammatory reactant. There are various explanations indicating the presence of higher ferritin levels in Still's disease. High ferritin tells us about disease severity, and prognosis and can also predict life-threatening complications that can be easily prevented and thus it helps in reducing mortality associated with Still's disease. However, there are certain limitations to the use of ferritin as the only diagnostic marker for Still's disease. Overcoming those limitations can take the diagnosis of Still's disease to a higher level.
Keywords
Still’s Disease; Ferritin; Arthritis
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
