Phylogenetic Reconstructions Reveal the Co-circulation of Different Lineages of Dengue Virus 2 in the Northern Region of Brazil: Insights into the Persistence of the Asian-American Genotype and the Introduction of the Cosmopolitan Genotype

Murilo Tavares Amorim; Felipe Gomes Naveca; Leonardo Henrique Almeida Hernández; Thito Yan Bezerra Da Paz; Cintia Cryslaine da Silva De Oliveira; Alessandra da Conceição Miranda Santos; Alice Louize Nunes Queiroz; Ana Lucia Monteiro Wanzeller; Eliana Vieira Pinto da Silva; Fábio Silva da Silva; Sandro Patroca da Silva; Bruno Tardelli Diniz Nunes; Ana Cecília Ribeiro Cruz

doi:10.20944/preprints202311.0566.v1

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202311.0566.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Phylogenetic Reconstructions Reveal the Co-circulation of Different Lineages of Dengue Virus 2 in the Northern Region of Brazil: Insights into the Persistence of the Asian-American Genotype and the Introduction of the Cosmopolitan Genotype

Murilo Tavares Amorim

^* ,

Felipe Gomes Naveca

Leonardo Henrique Almeida Hernández

Thito Yan Bezerra Da Paz

Cintia Cryslaine da Silva De Oliveira

Alessandra da Conceição Miranda Santos

Alice Louize Nunes Queiroz

Ana Lucia Monteiro Wanzeller

Eliana Vieira Pinto da Silva

Fábio Silva da Silva

Sandro Patroca da Silva

Bruno Tardelli Diniz Nunes

Ana Cecília Ribeiro Cruz

Version 1 : Received: 8 November 2023 / Approved: 8 November 2023 / Online: 8 November 2023 (15:42:03 CET)

A peer-reviewed article of this Preprint also exists.

Amorim, M.T.; Naveca, F.G.; Hernández, L.H.A.; da Paz, T.Y.B.; da Silva de Oliveira, C.C.; da Conceição Miranda Santos, A.; Queiroz, A.L.N.; Wanzeller, A.L.M.; da Silva, E.V.P.; da Silva, F.S.; da Silva, S.P.; Nunes, B.T.D.; Cruz, A.C.R. Detection of a Multiple Circulation Event of Dengue Virus 2 Strains in the Northern Region of Brazil. Trop. Med. Infect. Dis. 2024, 9, 17. Amorim, M.T.; Naveca, F.G.; Hernández, L.H.A.; da Paz, T.Y.B.; da Silva de Oliveira, C.C.; da Conceição Miranda Santos, A.; Queiroz, A.L.N.; Wanzeller, A.L.M.; da Silva, E.V.P.; da Silva, F.S.; da Silva, S.P.; Nunes, B.T.D.; Cruz, A.C.R. Detection of a Multiple Circulation Event of Dengue Virus 2 Strains in the Northern Region of Brazil. Trop. Med. Infect. Dis. 2024, 9, 17.

Abstract

Dengue virus serotype 2 (DENV-2) is responsible for dengue epidemics on a global scale and is recognized for being associated with severe cases of the disease. This study conducted the phylogenetic investigation of DENV-2 in the Northern region of Brazil. DENV-2 isolates from 2017 to 2021, originating from Northern Brazilian states, were selected. Only one lineage (I) of the Asian-American genotype and one lineage (5) of the cosmopolitan genotype were observed. All sequences of the Asian-American genotype used in this study were segregated into a paraphyletic subgroup aligned with sequences from an American clade. These results indicate a probable geographic link starting from Puerto Rico. Additionally, sequences from Acre were identified and grouped into a monophyletic clade of the cosmopolitan genotype. These results indicate the cocirculation of two DENV-2 distinct lineages: Lineage 1, Asian-American genotype (probable origin from Puerto Rico); Lineage 5, cosmopolitan genotype (probable origin from Peru). Our results provide important data regarding the study of DENV genotypes and lineages distribution, as well as opening up possibilities for probable introduction and dissemination routes.

Keywords

arboviruses; dengue virus serotype 2; cosmopolitan genotype; asian-american genotype

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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