The Therapeutic Potential of Pericytes in Bone Tissue Regeneration

Assel Issabekova; Aliya Sekenova; Vyacheslav Ogay; Gulshakhar Kudaibergen; Saule Eskendirova; Madina Sarsenova; Aidar Dairov; Sholpan Mukhlis; Murat Baidarbekov; Abay Temirzhan

doi:10.20944/preprints202311.0142.v1

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preprints.org > biology and life sciences > biology and biotechnology > doi: 10.20944/preprints202311.0142.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Therapeutic Potential of Pericytes in Bone Tissue Regeneration

Assel Issabekova

Aliya Sekenova

Vyacheslav Ogay

^* ,

Gulshakhar Kudaibergen

Version 1 : Received: 2 November 2023 / Approved: 2 November 2023 / Online: 2 November 2023 (09:55:56 CET)

A peer-reviewed article of this Preprint also exists.

Issabekova, A.; Kudaibergen, G.; Sekenova, A.; Dairov, A.; Sarsenova, M.; Mukhlis, S.; Temirzhan, A.; Baidarbekov, M.; Eskendirova, S.; Ogay, V. The Therapeutic Potential of Pericytes in Bone Tissue Regeneration. Biomedicines 2024, 12, 21. Issabekova, A.; Kudaibergen, G.; Sekenova, A.; Dairov, A.; Sarsenova, M.; Mukhlis, S.; Temirzhan, A.; Baidarbekov, M.; Eskendirova, S.; Ogay, V. The Therapeutic Potential of Pericytes in Bone Tissue Regeneration. Biomedicines 2024, 12, 21.

Abstract

Pericytes, as perivascular cells, are present in all vascularized organs and tissues, and they actively interact with endothelial cells in capillaries and microvessels. Their involvement includes functions like blood pressure regulation, tissue regeneration, and scarring. Studies have confirmed that pericytes play a crucial role in bone tissue regeneration through direct osteodifferentiation processes, paracrine actions, and vascularization. Recent pre-clinical and clinical experiments have shown that combining perivascular cells with osteogenic factors and tissue-engineered scaffolds can be therapeutically effective in restoring bone defects. This approach holds promise for addressing bone-related medical conditions. In this review, we have emphasized the characteristics of pericytes and their involvement in angiogenesis and osteogenesis. Furthermore, we have explored recent advancements in the use of pericytes in preclinical and clinical investigations, indicating their potential as a therapeutic resource in clinical applications.

Keywords

pericyte; osteogenesis; bone defect; regeneration

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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