Version 1
: Received: 1 November 2023 / Approved: 2 November 2023 / Online: 2 November 2023 (09:12:20 CET)
How to cite:
Tören, E.; Khan, M.; Militky, J.; Mazari, A.A.; Wiener, J. Fabrication of Pullulan/Polyvinyl Alcohol Core-Shell Nanofibers for Cancer Treatment and Drug Delivery. Preprints2023, 2023110140. https://doi.org/10.20944/preprints202311.0140.v1
Tören, E.; Khan, M.; Militky, J.; Mazari, A.A.; Wiener, J. Fabrication of Pullulan/Polyvinyl Alcohol Core-Shell Nanofibers for Cancer Treatment and Drug Delivery. Preprints 2023, 2023110140. https://doi.org/10.20944/preprints202311.0140.v1
Tören, E.; Khan, M.; Militky, J.; Mazari, A.A.; Wiener, J. Fabrication of Pullulan/Polyvinyl Alcohol Core-Shell Nanofibers for Cancer Treatment and Drug Delivery. Preprints2023, 2023110140. https://doi.org/10.20944/preprints202311.0140.v1
APA Style
Tören, E., Khan, M., Militky, J., Mazari, A.A., & Wiener, J. (2023). Fabrication of Pullulan/Polyvinyl Alcohol Core-Shell Nanofibers for Cancer Treatment and Drug Delivery. Preprints. https://doi.org/10.20944/preprints202311.0140.v1
Chicago/Turabian Style
Tören, E., Adnan Ahmed Mazari and Jakub Wiener. 2023 "Fabrication of Pullulan/Polyvinyl Alcohol Core-Shell Nanofibers for Cancer Treatment and Drug Delivery" Preprints. https://doi.org/10.20944/preprints202311.0140.v1
Abstract
This article discusses the fabrication of pullulan/polyvinyl alcohol (PVA) and PVA blends as carrier polymers for drug delivery. This study utilized coaxial electrospinning to encapsulate doxorubicin (DOX), a common anticancer drug, within nanofibers, which helped mitigate the adverse effects of DOX on normal cells. The study also demonstrated that the coaxial electrospinning technique using PVA/pullulan cores was effective in inhibiting the attachment and proliferation of HeLa cells, a type of cervical cancer cell. The use of pullulan/PVA and PVA blends as carrier polymers in conjunction with coaxial electrospinning could provide a safe and effective drug delivery system for the treatment of cervical and other solid malignancies. The study concluded that nanofibers showed promising results in inhibiting the growth of HeLa cells, indicating their potential as safe and effective drug delivery systems for treating cervical cancer and other solid malignant tumors.
Keywords
Electrospinning; Polysaccharides; Antibacterial; Cancer treatment; Core-shell nanofibers, Drug delivery systems
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
