Review
Version 1
Preserved in Portico This version is not peer-reviewed
Hemoadsorption in Organ Preservation and Transplantation: A Narrative Review
Version 1
: Received: 1 November 2023 / Approved: 1 November 2023 / Online: 1 November 2023 (12:28:25 CET)
A peer-reviewed article of this Preprint also exists.
García-Villegas, R.; Arni, S. Hemoadsorption in Organ Preservation and Transplantation: A Narrative Review. Life 2024, 14, 65. García-Villegas, R.; Arni, S. Hemoadsorption in Organ Preservation and Transplantation: A Narrative Review. Life 2024, 14, 65.
Abstract
Cytokine adsorption can resolve different complications characteristic of transplantation medicine, such cytokine storm activation, blood immuno- and AB0- incompatibilities but can also be performed for the treatment of various life-threatening conditions, such as sepsis, acute respiratory distress syndrome (ARDS), and cardiogenic shock, all of which can contribute to adverse clinical outcomes during transplantation. After surgery, dysmetabolism and stress response limit successful graft survival and can lead to primary (PGD) or secondary graft dysfunction. In this clinical context, and given that a major problem in transplant medicine is that the demand for organs far exceeds the supply, a technological innovation such as a hemoadsoption system could greatly contribute to increasing the number of usable organ donors. The objectives of this review are to describe the specific advantages and disadvantages of the application of cytokine adsorption in the context of transplantation and also to examine, before and/or after organ transplantation, the benefits of addition of a complementary cytokine adsorption therapy protocol.
Keywords
extracorporeal blood purification therapies; ex vivo lung perfusion; cytokine adsorption; hemoadsorption.
Subject
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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