Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Epidemiology of Antimicrobial Resistance Genes in Staphyloccocus aureus Isolates from a Public Database in a One Health Perspective – Sample Origin and Isolates Geographical Distribution

Francesca Zaghen
ORCID logo ,
Valerio Massimo Sora
* ORCID logo ,
Gabriele Meroni
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Giulia Laterza
ORCID logo ,
Piera Anna Martino
ORCID logo ,
Alessio Soggiu
ORCID logo ,
Luigi Bonizzi
,
Alfonso Zecconi
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Version 1 : Received: 31 October 2023 / Approved: 31 October 2023 / Online: 1 November 2023 (09:41:59 CET)

A peer-reviewed article of this Preprint also exists.

Zaghen, F.; Sora, V.M.; Meroni, G.; Laterza, G.; Martino, P.A.; Soggiu, A.; Bonizzi, L.; Zecconi, A. Epidemiology of Antimicrobial Resistance Genes in Staphylococcus aureus Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of Isolates. Antibiotics 2023, 12, 1654. Zaghen, F.; Sora, V.M.; Meroni, G.; Laterza, G.; Martino, P.A.; Soggiu, A.; Bonizzi, L.; Zecconi, A. Epidemiology of Antimicrobial Resistance Genes in Staphylococcus aureus Isolates from a Public Database from a One Health Perspective—Sample Origin and Geographical Distribution of Isolates. Antibiotics 2023, 12, 1654.

Abstract

Staphylococcus aureus are commensal bacteria present on skin and mucosae in both humans and animals, but they can also be found in food, water and in various environments. They are also considered a major pathogen having a great morbidity leading to a wide range of infections. They are included in the list of most virulent and antimicrobic resistant bacterial pathogens (ESKAPE, Escherichia coli, Staphylococcus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterococcus faecalis and faecium)) by the Center for Disease Control and Prevention (CDC), and S. aureus is part of the worldwide threat represented by the presence of antimicrobial resistance (AMR). The outcomes of an epidemiological investigation on 26,430 S. aureus isolates from a global public database (NPDIB; NCBI Pathogen Detection Isolate Browser) support the evidence of significant differences in the distribution of isolates and ARGs (Antimicrobial Resistance Genes) clusters among geographical areas of origin and among sources of the isolates. Moreover, the ARGs cluster patterns suggest an association between the isolates from human and animal populations. This outcome and the large diffusion of the pathogens among human and animal populations support the importance of gaining information on the epidemiology of these infections with a One Health approach.

Keywords

S. aureus; One Health; antimicrobial resistance; molecular epidemiology; geographical distribution.

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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