Review
Version 1
Preserved in Portico This version is not peer-reviewed
An Emerging Role for anti-DNA Antibodies in Systemic Lupus Erythematosus
Version 1
: Received: 31 October 2023 / Approved: 31 October 2023 / Online: 31 October 2023 (12:34:43 CET)
A peer-reviewed article of this Preprint also exists.
Kubota, T. An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2023, 24, 16499. Kubota, T. An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2023, 24, 16499.
Abstract
Anti-DNA antibodies are hallmark autoantibodies produced in systemic lupus erythematosus (SLE), but their pathogenetic roll is not fully understood. Accumulating evidence suggests that some anti-DNA antibodies enter different types of live cells and affect the pathophysiology of SLE by stimulating or impairing these cells. Circulating neutrophils in SLE are activated by type I interferon or other stimuli and primed to release neutrophil extracellular traps (NETs) on additional stimulation. Anti-DNA antibodies are also involved in this process and may induce NET release. Thereafter, they bind and protect extracellular DNA in the NETs from digestion by nucleases, resulting in increased NET immunogenicity. This review discusses the pathogenetic role of anti-DNA antibodies in SLE, mainly focusing on recent progress in the two research fields concerning antibody penetration into live cells and NETosis.
Keywords
anti-DNA antibodies; systemic lupus erythematosus (SLE); penetration; endocytosis; neutrophil extracellular traps (NETs); NETosis; pathogenesis
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
