Identification of Immune-Based Biomarkers Associated With Response to Abatacept (CTLA4-Ig) in Rheumatoid Arthritis Patients

Panagiota Goutakoli; Garyfalia Papadaki; Argyro Repa; Nestor Avgoustidis; Eleni Kalogiannaki; Irini D. Flouri; Antonios Bertsias; Jerome Zoidakis; Martina Samiotaki; George Bertsias; Maria Semitekolou; Panayotis Verginis; Prodromos Sidiropoulos

doi:10.20944/preprints202310.1896.v1

A peer-reviewed article of this Preprint also exists.

Goutakoli, P.; Papadaki, G.; Repa, A.; Avgoustidis, N.; Kalogiannaki, E.; Flouri, I.; Bertsias, A.; Zoidakis, J.; Samiotaki, M.; Bertsias, G.; Semitekolou, M.; Verginis, P.; Sidiropoulos, P. A Peripheral Blood Signature of Increased Th1 and Myeloid Cells Combined with Serum Inflammatory Mediators Is Associated with Response to Abatacept in Rheumatoid Arthritis Patients. Cells 2023, 12, 2808. Goutakoli, P.; Papadaki, G.; Repa, A.; Avgoustidis, N.; Kalogiannaki, E.; Flouri, I.; Bertsias, A.; Zoidakis, J.; Samiotaki, M.; Bertsias, G.; Semitekolou, M.; Verginis, P.; Sidiropoulos, P. A Peripheral Blood Signature of Increased Th1 and Myeloid Cells Combined with Serum Inflammatory Mediators Is Associated with Response to Abatacept in Rheumatoid Arthritis Patients. Cells 2023, 12, 2808.

Abstract

Abatacept (CTLA4-Ig) – a monoclonal antibody which restricts T cell activation – is an effective treatment for rheumatoid arthritis (RA). Herein, we aimed to investigate for biomarkers of response to abatacept. We performed a detailed immunological profiling of CTLA4-treated RA patients’ peripheral blood (PB) cells and sera using flow cytometry and proteomics analysis, respectively. At 6 months of treatment, 34.5% of patients attained clinical response. Notably, baseline levels of Th1 and myeloid cell populations were significantly elevated in PB of responders compared to non-responders (P-value<0.05). Additionally, proteomics analysis revealed 10 amongst 303 molecules which were associated with clinical responses. Should the present data be confirmed in a larger cohort could be of clinical value.

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Identification of Immune-Based Biomarkers Associated With Response to Abatacept (CTLA4-Ig) in Rheumatoid Arthritis Patients

Abstract

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Subject

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