Baranova, K.; Nalivaeva, N.; Rybnikova, E. Neuroadaptive Biochemical Mechanisms of Remote Ischemic Conditioning. Int. J. Mol. Sci.2023, 24, 17032.
Baranova, K.; Nalivaeva, N.; Rybnikova, E. Neuroadaptive Biochemical Mechanisms of Remote Ischemic Conditioning. Int. J. Mol. Sci. 2023, 24, 17032.
Baranova, K.; Nalivaeva, N.; Rybnikova, E. Neuroadaptive Biochemical Mechanisms of Remote Ischemic Conditioning. Int. J. Mol. Sci.2023, 24, 17032.
Baranova, K.; Nalivaeva, N.; Rybnikova, E. Neuroadaptive Biochemical Mechanisms of Remote Ischemic Conditioning. Int. J. Mol. Sci. 2023, 24, 17032.
Abstract
This review summarizes the currently known biochemical neuroadaptive mechanisms of remote ischemic conditioning. In particular, it focuses on the significance of the pro-adaptive effects of remote ischemic conditioning, which allow prevention of neurological and cognitive impairments associated with hippocampal dysregulation after brain damage. The neuro-immuno-humoral pathway of transmitting a conditioning stimulus, as well as the molecular basis of the early and delayed phases of neuroprotection, including anti-apoptotic, antioxidant and anti-inflammatory components, are also outlined. Based on the close interplay between the effects of ischemia, especially mediated by interaction of HIF factors and steroid hormones, the involvement of the hypothalamic-pituitary-adrenocortical system in remote ischemic conditioning is also discussed.
Keywords
ischemic conditioning; brain; hippocampus; adaptation; mechanisms of neuroprotection; HIF-1; HPA
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
