Version 1
: Received: 24 October 2023 / Approved: 25 October 2023 / Online: 25 October 2023 (11:29:20 CEST)
How to cite:
Lobascio, F.; Fiore, M.; Di Modugno, N.; Bruno, C.; De Nicolo, T.; Di Modugno, R.; Barberis, R.V.; Cabiale, K.; Radoiu, M. Microwave and Radiofrequency Ablation: A Comparative Study between Technologies in Ex-Vivo Tissues. Preprints2023, 2023101643. https://doi.org/10.20944/preprints202310.1643.v1
Lobascio, F.; Fiore, M.; Di Modugno, N.; Bruno, C.; De Nicolo, T.; Di Modugno, R.; Barberis, R.V.; Cabiale, K.; Radoiu, M. Microwave and Radiofrequency Ablation: A Comparative Study between Technologies in Ex-Vivo Tissues. Preprints 2023, 2023101643. https://doi.org/10.20944/preprints202310.1643.v1
Lobascio, F.; Fiore, M.; Di Modugno, N.; Bruno, C.; De Nicolo, T.; Di Modugno, R.; Barberis, R.V.; Cabiale, K.; Radoiu, M. Microwave and Radiofrequency Ablation: A Comparative Study between Technologies in Ex-Vivo Tissues. Preprints2023, 2023101643. https://doi.org/10.20944/preprints202310.1643.v1
APA Style
Lobascio, F., Fiore, M., Di Modugno, N., Bruno, C., De Nicolo, T., Di Modugno, R., Barberis, R.V., Cabiale, K., & Radoiu, M. (2023). Microwave and Radiofrequency Ablation: A Comparative Study between Technologies in Ex-Vivo Tissues. Preprints. https://doi.org/10.20944/preprints202310.1643.v1
Chicago/Turabian Style
Lobascio, F., Karine Cabiale and Marilena Radoiu. 2023 "Microwave and Radiofrequency Ablation: A Comparative Study between Technologies in Ex-Vivo Tissues" Preprints. https://doi.org/10.20944/preprints202310.1643.v1
Abstract
In this paper we report on the use of an in-house developed solid-state hybrid microwave and radiofrequency generator operating at frequencies of 2.45 GHz and/or 480 kHz for cancer ablation in various tissues. The generator has demonstrated increased accuracy due to its custom-designed hardware, which incorporates the latest technologies and algorithms to control the emitted power versus temperature profile of the treated sample. In particular, the hybrid generator incorporates control systems based on impedance or reflected power measurements that allow controlled ablation without causing unwanted carbonisation and without including areas where tissue damage is not desired.
Tests performed ex-vivo on chicken breast and bovine liver show that radiofrequency ablation (RFA) is very effective for performing controlled ablations with minimally invasive probes, such as cardiac pathologies, small lesions, tissues with particular composition, while microwave ablation (MWA) is optimal for performing large ablations in highly vascularised tissues, such as liver cancer, where it is necessary to achieve higher temperatures.
Keywords
microwaves; radiofrequency; medical applications; medical equipment; solid-state; tissue ablation; cancer; temperature control; ex-vivo
Subject
Engineering, Bioengineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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