Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Prognostic Indicators of Autoimmune Inner Ear Disease in a Case Series

Hsun-Hua Lee
ORCID logo ,
Hann-Ziong Yueh
ORCID logo ,
Tu-Hsueh Yeh
,
Chaur-Jong Hu
ORCID logo ,
Fei-Peng Lee
,
Cheng-Chang Yang
ORCID logo ,
Kent Lin
,
Han-Sheng Chang
,
Che-Hsuan Lin
*
Version 1 : Received: 23 October 2023 / Approved: 24 October 2023 / Online: 25 October 2023 (10:21:22 CEST)

How to cite: Lee, H.; Yueh, H.; Yeh, T.; Hu, C.; Lee, F.; Yang, C.; Lin, K.; Chang, H.; Lin, C. Prognostic Indicators of Autoimmune Inner Ear Disease in a Case Series. Preprints 2023, 2023101638. https://doi.org/10.20944/preprints202310.1638.v1 Lee, H.; Yueh, H.; Yeh, T.; Hu, C.; Lee, F.; Yang, C.; Lin, K.; Chang, H.; Lin, C. Prognostic Indicators of Autoimmune Inner Ear Disease in a Case Series. Preprints 2023, 2023101638. https://doi.org/10.20944/preprints202310.1638.v1

Abstract

Background: Autoimmune inner ear disease (AIED) is a rare autoimmune condition characterized by progressive sensorineural hearing loss with hearing fluctuations over weeks to months, presenting significant challenges in both diagnosis and treatment. Due to its rarity, treatment responses and prognosis in AIED remain poorly understood. Methods: This study reviewed medical records from Taipei Medical University Hospital documented between August 2016 and August 2021. Among 67 patients experiencing fluctuating hearing loss, 11 met the diagnostic criteria for AIED and underwent regular follow-up assessments within a 5-year timeframe. ROC curve was used to discriminate the power of these prognostic parameters. Results: In this study, several factors including younger age, milder initial hearing loss, meeting criteria for bilateral Meniere's disease (MD), having an ascending audiogram pattern, longer time interval between hearing impairment attacks in contralateral ears and responding well to steroids were associated with better prognosis. ROC curve demonstrated the diagnostic value of specific parameters such as the presence of bilateral MD (AUC 0.825, 95% CI 0.640–1.000), pretreatment HI ≤ 45 dB HL (AUC 0.808, 95% CI 0.610–1.000), response to steroids (AUC 0.800, 95% CI 0.595–1.000), and ascending audiogram (AUC 0.858, 95% CI 0.683–0.858). Conclusions: This study identified key prognostic factors for AIED, providing valuable insights for predicting AIED prognosis and facilitating personalized patient management.

Keywords

autoimmune inner ear disease; sensorineural hearing loss; Meniere’s disease

Subject

Medicine and Pharmacology, Otolaryngology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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