Version 1
: Received: 20 October 2023 / Approved: 23 October 2023 / Online: 24 October 2023 (08:39:18 CEST)
How to cite:
De Moura Campos, M.; Pagliarini, E.; Locks, A.; Gonçalves, M. Lambert Eaton Myasthenic Syndrome: A Bridge Diagnostic For Occult Tumor. Preprints2023, 2023101503. https://doi.org/10.20944/preprints202310.1503.v1
De Moura Campos, M.; Pagliarini, E.; Locks, A.; Gonçalves, M. Lambert Eaton Myasthenic Syndrome: A Bridge Diagnostic For Occult Tumor. Preprints 2023, 2023101503. https://doi.org/10.20944/preprints202310.1503.v1
De Moura Campos, M.; Pagliarini, E.; Locks, A.; Gonçalves, M. Lambert Eaton Myasthenic Syndrome: A Bridge Diagnostic For Occult Tumor. Preprints2023, 2023101503. https://doi.org/10.20944/preprints202310.1503.v1
APA Style
De Moura Campos, M., Pagliarini, E., Locks, A., & Gonçalves, M. (2023). Lambert Eaton Myasthenic Syndrome: A Bridge Diagnostic For Occult Tumor. Preprints. https://doi.org/10.20944/preprints202310.1503.v1
Chicago/Turabian Style
De Moura Campos, M., Amanda Locks and Marcus Gonçalves. 2023 "Lambert Eaton Myasthenic Syndrome: A Bridge Diagnostic For Occult Tumor" Preprints. https://doi.org/10.20944/preprints202310.1503.v1
Abstract
Lambert-Eaton myasthenic syndrome is a primary autoimmune or paraneoplastic neuromuscular disorder, which causes muscle weakness, areflexia and autonomic disorders through the production of antibodies to voltage-gated calcium channels. Diagnosis may be challenging, yet at the same time extremely important, allowing the detection of a possible underlying malignancy, in cases of paraneoplastic presentation. Some antibodies have good sensitivity and specificity for malignancy and are also discussed. Although most of times being correlated to small cell lung cancer, other types of tumors may be also found in the paraneoplastic syndrome. Misdiagnosis with Myasthenia Gravis may occur and differences between these two disorders are discussed. Therapy choice may vary from each patient depending on drug response and the situation in which the patient is encounter. Overall, the present paper brings a review of Lambert-Eaton, involving the diagnosis, as well as, the pathophysiology, differential diagnosis, tumor investigation and treatment. Also, a brief overview through guidance on therapy during the Corona Virus Disease 2019 pandemic is analyzed.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
