Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation, Nanosafety Evaluation

Mathilde Ménard
* ,
Lamiaa M.A. Ali
* ,
Ani Vardanyan
* ORCID logo ,
Clarence Charnay
ORCID logo ,
Laurence Raehm
,
Frédérique Cunin
,
Aurélie Bessière
ORCID logo ,
Erwan Oliviero
ORCID logo ,
Theodossis A. Theodossiou
,
Gulaim A. Seisenbaeva
ORCID logo ,
Magali Gary-Bobo
ORCID logo ,
Jean-Olivier Durand
ORCID logo
Version 1 : Received: 23 October 2023 / Approved: 23 October 2023 / Online: 23 October 2023 (09:54:08 CEST)

A peer-reviewed article of this Preprint also exists.

Ménard, M.; Ali, L.M.A.; Vardanyan, A.; Charnay, C.; Raehm, L.; Cunin, F.; Bessière, A.; Oliviero, E.; Theodossiou, T.A.; Seisenbaeva, G.A.; Gary-Bobo, M.; Durand, J.-O. Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation: Nanosafety Evaluation. Nanomaterials 2023, 13, 3155. Ménard, M.; Ali, L.M.A.; Vardanyan, A.; Charnay, C.; Raehm, L.; Cunin, F.; Bessière, A.; Oliviero, E.; Theodossiou, T.A.; Seisenbaeva, G.A.; Gary-Bobo, M.; Durand, J.-O. Upscale Synthesis of Magnetic Mesoporous Silica Nanoparticles and Application to Metal Ion Separation: Nanosafety Evaluation. Nanomaterials 2023, 13, 3155.

Abstract

(1) Background: The synthesis of core-shell magnetic mesoporous nanoparticles (MMSN) from phase transfer process is usually performed at 100-250 mg scale. At the gram scale, nanoparticles without core or with multicore systems are observed. (2) Methods: Iron oxide core nanoparticles (IO) were synthesized through thermal decomposition procedure of -FeO in oleic acid. Phase transfer from chloroform to water was then performed in order to wrap IO with mesoporous silica shell through the sol-gel procedure. MMSN were then functionalized with DTPA, and used for the separation of metal ions. Their toxicity was evaluated (3) Results: The phase transfer pro-cedure was crucial to obtained MMSN at large scale. Three synthesis parameters were rigorously controlled: temperature, time and glassware. Homogeneous dispersion of MMSN at the gram scale was successfully obtained. After functionalization with DTPA, the MMSN-DTPA were shown to have a strong affinity for Ni ions. Furthermore toxicity was evaluated in cells, zebrafish and through seahorse metabolic assays, and the nanoparticles were found nontoxic. (4) Conclusions: We developed a method of preparation of MMSN at the gram scale. After function-alization with DTPA, the nanoparticles were efficient in metal ion removal and separation, fur-thermore, no toxicity was noticed up to 125 µg.mL-1 in zebrafish.

Keywords

Magnetic Mesoporous Nanoparticles; Up scaled synthesis. DTPA; Metal ion separation, Toxicity

Subject

Chemistry and Materials Science, Materials Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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