Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Hydrogel Membranes from Chitosan-Fish Gelatin-Glycerol for Biomedical Applications. Chondroitin Sulfate Incorporation Effect in Membrane Properties

Andreas Karydis-Messinis
* ,
Dimitrios Moschovas
,
Maria Markou
,
Kyriaki Tsirka
ORCID logo ,
Christina Gioti
,
Eleni Bagli
,
Carol Murphy
,
Aris E. Giannakas
ORCID logo ,
Alkiviadis S. Paipetis
ORCID logo ,
Michael A. Karakassides
,
Apostolos Avgeropoulos
ORCID logo ,
Constantinos E. Salmas
* ORCID logo ,
Nikolaos E. Zafeiropoulos
* ORCID logo
Version 1 : Received: 18 October 2023 / Approved: 18 October 2023 / Online: 19 October 2023 (20:17:37 CEST)

A peer-reviewed article of this Preprint also exists.

Karydis-Messinis, A.; Moschovas, D.; Markou, M.; Tsirka, K.; Gioti, C.; Bagli, E.; Murphy, C.; Giannakas, A.E.; Paipetis, A.; Karakassides, M.A.; Avgeropoulos, A.; Salmas, C.E.; Zafeiropoulos, N.E. Hydrogel Membranes from Chitosan-Fish Gelatin-Glycerol for Biomedical Applications: Chondroitin Sulfate Incorporation Effect in Membrane Properties. Gels 2023, 9, 844. Karydis-Messinis, A.; Moschovas, D.; Markou, M.; Tsirka, K.; Gioti, C.; Bagli, E.; Murphy, C.; Giannakas, A.E.; Paipetis, A.; Karakassides, M.A.; Avgeropoulos, A.; Salmas, C.E.; Zafeiropoulos, N.E. Hydrogel Membranes from Chitosan-Fish Gelatin-Glycerol for Biomedical Applications: Chondroitin Sulfate Incorporation Effect in Membrane Properties. Gels 2023, 9, 844.

Abstract

Biomass and biowaste valorisation is of major interest nowadays because of the spirit of circular economy and of the neutral environmental fingerprint global target. In the current project chondroitin sulphate (ChS) was incorporated with the crustaceous’ and shrimp’s byproduct chitosan (Chi) and the fish industry byproduct gelatine (FG) to obtain dense hydrogel membranes. Glycerol (Gly) was utilized to avoid brittleness. The formation of the hydrogel membranes is attributed to secondary interactions between the natural polymers and the plasticizer. The prepared hydrogel membranes were characterized by Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The surface morphology of the membranes was examined using scanning electron microscopy (SEM). Dynamic mechanical analysis (DMA) and tensile tests were also performed to evaluate the mechanical response of the membranes. The samples were also evaluated for membrane wettability, degradation rate and water vapor transmission rate (WVTR). Finally, in vitro endothelial cell attachment on the membrane were addressed. The overall results of the study indicate that the hydrogel membranes could be appropriate for external application in wound healing applications as dressings.

Keywords

chitosan; fish gelatin; chondroitin sulfate; hydrogel membranes; wound dressing; in vitro cell colonization; gelatin glycerol; biomedical applications; membranes

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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