Version 1
: Received: 18 October 2023 / Approved: 19 October 2023 / Online: 19 October 2023 (10:07:32 CEST)
How to cite:
Montgomery, M.; Ritchie, M.; McKinnell, I. Can Melatonin Ameliorate Smoking-Related Cadmium-Induced Decreases in Bone Mineral Density?. Preprints2023, 2023101236. https://doi.org/10.20944/preprints202310.1236.v1
Montgomery, M.; Ritchie, M.; McKinnell, I. Can Melatonin Ameliorate Smoking-Related Cadmium-Induced Decreases in Bone Mineral Density?. Preprints 2023, 2023101236. https://doi.org/10.20944/preprints202310.1236.v1
Montgomery, M.; Ritchie, M.; McKinnell, I. Can Melatonin Ameliorate Smoking-Related Cadmium-Induced Decreases in Bone Mineral Density?. Preprints2023, 2023101236. https://doi.org/10.20944/preprints202310.1236.v1
APA Style
Montgomery, M., Ritchie, M., & McKinnell, I. (2023). Can Melatonin Ameliorate Smoking-Related Cadmium-Induced Decreases in Bone Mineral Density?. Preprints. https://doi.org/10.20944/preprints202310.1236.v1
Chicago/Turabian Style
Montgomery, M., Marshall Ritchie and Iain McKinnell. 2023 "Can Melatonin Ameliorate Smoking-Related Cadmium-Induced Decreases in Bone Mineral Density?" Preprints. https://doi.org/10.20944/preprints202310.1236.v1
Abstract
Cadmium, an environmental toxin, is associated with a range of adverse health effects due to increased Reactive Oxygen Species production, including decreased bone mineral density and osteoporosis. Notably, cadmium is found at concentrations 4-5x higher in the blood of smokers versus non-smokers. Experiments performed in human cancer cells indicate that melatonin may directly protect against cadmium-induced tissue damage via regulation of mitochondrial activity. Further, recent evidence has demonstrated that melatonin can improve bone health for individuals with osteoporosis and partially protect against cadmium-associated inhibition of bone repair. Here we review this data and propose supplementation with melatonin as a strategy to protect against the negative impacts of cadmium exposure on bone mineral density within individuals regularly exposed to cadmium via cigarette smoking.
Keywords
cadmium; bone density; cigarette; melatonin; smoking; osteoblast
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
