Version 1
: Received: 18 October 2023 / Approved: 18 October 2023 / Online: 19 October 2023 (08:09:26 CEST)
How to cite:
Jumabaev, F.; Khayrullaev, D.; Zakirova, R.; Abdunazarov, A.; Sharipov, A. Synthesis, Structure, DFT and In Silico Studies of Zn (II) Complex with Lipoic Acid: A Potential Antidiabetic Drug. Preprints2023, 2023101193. https://doi.org/10.20944/preprints202310.1193.v1
Jumabaev, F.; Khayrullaev, D.; Zakirova, R.; Abdunazarov, A.; Sharipov, A. Synthesis, Structure, DFT and In Silico Studies of Zn (II) Complex with Lipoic Acid: A Potential Antidiabetic Drug. Preprints 2023, 2023101193. https://doi.org/10.20944/preprints202310.1193.v1
Jumabaev, F.; Khayrullaev, D.; Zakirova, R.; Abdunazarov, A.; Sharipov, A. Synthesis, Structure, DFT and In Silico Studies of Zn (II) Complex with Lipoic Acid: A Potential Antidiabetic Drug. Preprints2023, 2023101193. https://doi.org/10.20944/preprints202310.1193.v1
APA Style
Jumabaev, F., Khayrullaev, D., Zakirova, R., Abdunazarov, A., & Sharipov, A. (2023). Synthesis, Structure, DFT and In Silico Studies of Zn (II) Complex with Lipoic Acid: A Potential Antidiabetic Drug. Preprints. https://doi.org/10.20944/preprints202310.1193.v1
Chicago/Turabian Style
Jumabaev, F., Azamat Abdunazarov and Avez Sharipov. 2023 "Synthesis, Structure, DFT and In Silico Studies of Zn (II) Complex with Lipoic Acid: A Potential Antidiabetic Drug" Preprints. https://doi.org/10.20944/preprints202310.1193.v1
Abstract
Zinc, being a part of many proteins and enzymes, plays an important role in the vital processes of the body. Racemic α-lipoic acid (LA) has a wide range of biological activities: antioxidant, antidiabetic, anticancer, and it is also used in diseases such as Parkinson's and Alzheimer's. Nowadays, the synthesis and structural studies of new zinc complexes with biologically active compounds are of great importance for drug discovery. This work shows the studies carried out on the synthesis, structure, identification, also biological activity using in silico methods of a complex compound based on LA and zinc. A complex compound of zinc with LA (ZnLA) was synthesized in the presence of LA and zinc acetate in ethanol. The identification of ZnLA by (FT-IR, XRD and TGA-DTA), also DFT calculations at the B3LYP/def2-TZVPP level of theory was performed. The molecular docking investigation involved docking ZnLA with two different protein receptors such us Glycogen phosphorylase (2GPA) and Kv potassium channel beta subunit (1ZSX) using CB-Dock 2 server and Auto-Dock Vina program to determine the mechanism of action and biological activity. This study reveals potential ligand-protein interactions at the atomic level and suggests that the treatment of diabetes (non-insulin dependent) with ZnLA.
Chemistry and Materials Science, Inorganic and Nuclear Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
