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Characteristics of Interpolyelectrolyte Complexes Based on Different Types of Pectin with Eudragit® E PO as Novel Carriers for Colon-Specific Drug Delivery
Nasibullin, S.F.; Dunaeva, J.V.; Akramova, L.A.; Timergalieva, V.R.; Moustafine, R.I. Characteristics of Interpolyelectrolyte Complexes Based on Different Types of Pectin with Eudragit® EPO as Novel Carriers for Colon-Specific Drug Delivery. Int. J. Mol. Sci.2023, 24, 17622.
Nasibullin, S.F.; Dunaeva, J.V.; Akramova, L.A.; Timergalieva, V.R.; Moustafine, R.I. Characteristics of Interpolyelectrolyte Complexes Based on Different Types of Pectin with Eudragit® EPO as Novel Carriers for Colon-Specific Drug Delivery. Int. J. Mol. Sci. 2023, 24, 17622.
Nasibullin, S.F.; Dunaeva, J.V.; Akramova, L.A.; Timergalieva, V.R.; Moustafine, R.I. Characteristics of Interpolyelectrolyte Complexes Based on Different Types of Pectin with Eudragit® EPO as Novel Carriers for Colon-Specific Drug Delivery. Int. J. Mol. Sci.2023, 24, 17622.
Nasibullin, S.F.; Dunaeva, J.V.; Akramova, L.A.; Timergalieva, V.R.; Moustafine, R.I. Characteristics of Interpolyelectrolyte Complexes Based on Different Types of Pectin with Eudragit® EPO as Novel Carriers for Colon-Specific Drug Delivery. Int. J. Mol. Sci. 2023, 24, 17622.
Abstract
Many studies have been conducted using pectin for modified drug delivery. In this regard, the goal of the work was to obtain interpolyelectrolyte complexes based on citrus or apple pectin and the Eudragit® EPO and study properties from the standpoint of using these carriers for oral drug delivery. Turbidity, gravimetry, viscosity, elementary analysis and FTIR spectroscopy, DSC analysis were used for physicochemical characterization. Diffusion-transport characteristics were studied to assess the swelling ability of the matrices and the release of diclofenac sodium. Mathematical modeling of the release parameters was carried out using the Krosmayer-Peppas equation. During the turbidity study, stoichiometry compositions were selected for the studied IPECs EPO/PeсA and EPO/PeсC at pH values = 4.0, 5.0, 6.0, 7.0. FTIR spectra of the complexes are characterized by an increase in the intensity of the bands at 1610 cm-1 and 1400 cm-1. According to the DSC analysis IPEC has a certain Tg = 57.3°C. The highest release rates are shown by IPEC EPO/PecC_1 and EPO/PecC_4. The mechanism of drug transport from the matrices IPEC EPO/PecC, IPEC EPO/PecA_3 and EPO/PecA_4 can be characterized as Super Case II. Anomalous (non-Fickian release) is typical for IPEC EPO/PecA_1 and EPO/PecA_2. Thus, the resulting systems are suitable for colon-specific drug delivery systems.
Keywords
Eudragit® E РО; citrus pectin; apple pectin; diclofenac sodium; interpolyelectrolyte complex
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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