Drača, N.; Orešković, E.G.; Lazić, R.; Vukojević, M.; Radolović Bertetić, A.; Vukojević, N. Management of Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP)—A Case Report. Medicina2023, 59, 2158.
Drača, N.; Orešković, E.G.; Lazić, R.; Vukojević, M.; Radolović Bertetić, A.; Vukojević, N. Management of Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP)—A Case Report. Medicina 2023, 59, 2158.
Drača, N.; Orešković, E.G.; Lazić, R.; Vukojević, M.; Radolović Bertetić, A.; Vukojević, N. Management of Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP)—A Case Report. Medicina2023, 59, 2158.
Drača, N.; Orešković, E.G.; Lazić, R.; Vukojević, M.; Radolović Bertetić, A.; Vukojević, N. Management of Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP)—A Case Report. Medicina 2023, 59, 2158.
Abstract
Background and Objectives: A 62-year-old patient presented with significant visual reduction in the last three months. Best corrected visual acuity (BCVA) of the right eye (RE) dropped from 20/20 on both eyes to 20/200 on the RE and counting fingers (CF) on the left eye (LE); respectfully. She was diagnosed with stage 4 ovarian cancer 1 month ago. Materials and Methods: Examination revealed significant progression of cataracts and subretinal fluid on the posterior pole with choroidal thickening. Multifocal, orange-pigmented elevated choroidal lesions were observed in the RE, while the view of the left eye fundus was obstructed by cataracts. OCT revealed bilateral choroidal thickening with overlying folds and subretinal fluid and ultrasound of the choroidal lesions showed moderate homogenous internal reflectivity. Results: The patient was diagnosed with BDUMP (bilateral diffuse uveal melanocytic proliferation), a paraneoplastic syndrome characterised by simultaneous, bilateral, painless vision loss and rapidly acquired bilateral cataracts with serous retinal detachments. Cataract extraction had not obtained the expected visual recovery (RE: CF; LE 2/200, respectfully). Plasmapheresis demonstrated some success by stabilizing vision loss obtained by serous retinal detachments. Conclusion: The focus of treating BDUMP is aimed at the underlying malignancy. Vision typically deteriorates to near blindness within a year from presentation. Overall prognosis is generally poor and mean survival is reported at 12-15.7 months from the time of ocular diagnosis.
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