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Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan
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: Received: 12 October 2023 / Approved: 13 October 2023 / Online: 16 October 2023 (08:19:35 CEST)
A peer-reviewed article of this Preprint also exists.
Lee, Y.; Jang, J.; Na, S.J. Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan. Diagnostics 2023, 13, 3342. Lee, Y.; Jang, J.; Na, S.J. Diffuse Cardiac Uptake Misdiagnosed as Cardiac Amyloidosis in Bone Scan. Diagnostics 2023, 13, 3342.
Abstract
In this presented case, a 77 years old woman suffering from ongoing knee pain underwent a bone scan using 99mTc-hydroxydiphosphonate (HDP) in suspicious for bone infection. An incidental finding from this scan revealed diffuse cardiac uptake, necessitating further diagnostic procedures to exclude the possibility of cardiac amyloidosis. In the subsequent 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan and SPECT images, no perceptible cardiac uptake was observed at all. Upon retrospective review of the patient’s medical records, she had received 1000mg of ferric carboxymaltose for iron-deficient anemia, the day before the 99mTc-HDP bone scan. Therefore, it is assumed that the diffuse and temporary cardiac activity was due to the transient iron overload. We present and share this bone scan images in order to avoid possible future misinterpretation of cardiac amyloidosis.
Keywords
bone scan; 99mTc-HDP; cardiac amyloidosis; iron overload
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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