Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta

Version 1 : Received: 12 October 2023 / Approved: 13 October 2023 / Online: 13 October 2023 (07:58:19 CEST)

A peer-reviewed article of this Preprint also exists.

Wątroba, M.; Szewczyk, G.; Szukiewicz, D. The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta. Int. J. Mol. Sci. 2023, 24, 16210. Wątroba, M.; Szewczyk, G.; Szukiewicz, D. The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta. Int. J. Mol. Sci. 2023, 24, 16210.

Abstract

Sirtuins, especially SIRT1, play a significant role in the regulation of inflammatory response, autophagy, and cell response to oxidative stress. Since their discovery, sirtuins have been regarded as anti-aging and longevity-promoting enzymes. Sirtuin-regulated processes seem to take part in most prevalent placental pathologies, such as preeclampsia. Furthermore, more and more research studies indicate that SIRT1 may prevent pre-eclampsia development, or at least alleviate its manifestations. Having taken this into consideration, we have made a review of recent studies on the role of sirtuins, especially SIRT1, in the regulation of processes determining normal or abnormal development and functioning of the placenta.

Keywords

sirtuin-1; SIRT1; sirtuins; human placenta; placental physiology; placental pathophysiology; preeclampsia; peroxisome proliferator-activated receptor γ; PPARγ; SIRT1/PPARγ signaling

Subject

Medicine and Pharmacology, Reproductive Medicine

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