An Overview of Golgi Membrane-Associated Degradation and Its Detection Methods

Hajime Tajima Sakurai; Satoko Arakawa; Hirofumi Yamaguchi; Satoru Torii; Shinya Honda; Shigeomi Shimizu

doi:10.20944/preprints202310.0839.v1

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preprints.org > biology and life sciences > cell and developmental biology > doi: 10.20944/preprints202310.0839.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

An Overview of Golgi Membrane-Associated Degradation and Its Detection Methods

Hajime Tajima Sakurai

Version 1 : Received: 11 October 2023 / Approved: 12 October 2023 / Online: 13 October 2023 (07:47:25 CEST)

A peer-reviewed article of this Preprint also exists.

Sakurai, H.T.; Arakawa, S.; Yamaguchi, H.; Torii, S.; Honda, S.; Shimizu, S. An Overview of Golgi Membrane-Associated Degradation (GOMED) and Its Detection Methods. Cells 2023, 12, 2817. Sakurai, H.T.; Arakawa, S.; Yamaguchi, H.; Torii, S.; Honda, S.; Shimizu, S. An Overview of Golgi Membrane-Associated Degradation (GOMED) and Its Detection Methods. Cells 2023, 12, 2817.

Abstract

Autophagy is a cellular mechanism that utilizes lysosomes to degrade its own components and is performed using Atg5 and other molecules originating from the endoplasmic reticulum membrane. On the other hand, we identified an alternative type of autophagy, namely, Golgi membrane-associated degradation (GOMED), which also utilizes lysosomes to degrade its own components, but does not use Atg5 originating from the Golgi membranes. The GOMED pathway involves Ulk1, Wipi3, Rab9 and other molecules, and plays crucial roles in a wide range of biological phenomena, such as the regulation of insulin secretion and neuronal maintenance. We here describe the overview of GOMED, the methods to detect autophagy and GOMED, and to distinguish GOMED from autophagy.

Keywords

GOMED; alternative autophagy; Golgi

Subject

Biology and Life Sciences, Cell and Developmental Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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