Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Impaired Angiogenic Function of Fetal Endothelial Progenitor Cells via PCDH10 Overexpression in Gestational Diabetes Mellitus

Hayan Kwon
,
Yun Ji Jung
ORCID logo ,
Yeji Lee
,
Ga-Hyun Son
ORCID logo ,
Hyun Ok Kim
,
Yong-Sun Maeng
* ,
Ja-Young Kwon
* ORCID logo
Version 1 : Received: 11 October 2023 / Approved: 11 October 2023 / Online: 11 October 2023 (17:26:31 CEST)

A peer-reviewed article of this Preprint also exists.

Kwon, H.; Jung, Y.J.; Lee, Y.; Son, G.-H.; Kim, H.O.; Maeng, Y.-S.; Kwon, J.-Y. Impaired Angiogenic Function of Fetal Endothelial Progenitor Cells via PCDH10 in Gestational Diabetes Mellitus. Int. J. Mol. Sci. 2023, 24, 16082. Kwon, H.; Jung, Y.J.; Lee, Y.; Son, G.-H.; Kim, H.O.; Maeng, Y.-S.; Kwon, J.-Y. Impaired Angiogenic Function of Fetal Endothelial Progenitor Cells via PCDH10 in Gestational Diabetes Mellitus. Int. J. Mol. Sci. 2023, 24, 16082.

Abstract

Maternal hyperglycemia, induced by gestational diabetes mellitus (GDM), has detrimental effects on fetal vascular development, ultimately increasing the risk of cardiovascular diseases in offspring. The potential underlying mechanisms by which these complications occur are through functional impairment and epigenetic changes in fetal endothelial progenitor cells (EPCs), however, remain less defined. We confirm that intrauterine hyperglycemia leads to impaired angiogenic function of fetal EPCs, as observed through functional assays of outgrowth endothelial cells (OECs) derived from fetal EPCs of GDM pregnancies (GDM-EPCs). Notably, PCDH10 expression is increased in OECs derived from GDM-EPCs, which is associated with the inhibition of angiogenic function in fetal EPCs. Additionally, increased PCDH10 expression is correlated with hypomethylation of the PCDH10 promoter. Our findings demonstrate that in utero exposure to GDM can induce angiogenic dysfunction in fetal EPCs through altered gene expression and epigenetic changes, consequently increasing the susceptibility to cardiovascular diseases in offspring of GDM mothers.

Keywords

gestational diabetes mellitus; endothelial progenitor cells; angiogenesis; PCDH10; epigenetic changes

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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