Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Desmoid Fibromatosis of the Anterior Abdominal Wall in Pregnancy: A Case Report and Review of the Literature

Version 1 : Received: 10 October 2023 / Approved: 10 October 2023 / Online: 10 October 2023 (10:45:54 CEST)

A peer-reviewed article of this Preprint also exists.

Zubor, P.; Henriksen, C.M.; Økstad, M.E.; Cerskuviene, E.; Visnovsky, J.; Kajo, K.; Valkov, A.; Lind, K.O. Desmoid Fibromatosis of the Anterior Abdominal Wall in Pregnancy: A Case Report and Review of the Literature. Diseases 2024, 12, 27, doi:10.3390/diseases12010027. Zubor, P.; Henriksen, C.M.; Økstad, M.E.; Cerskuviene, E.; Visnovsky, J.; Kajo, K.; Valkov, A.; Lind, K.O. Desmoid Fibromatosis of the Anterior Abdominal Wall in Pregnancy: A Case Report and Review of the Literature. Diseases 2024, 12, 27, doi:10.3390/diseases12010027.

Abstract

Introduction: Desmoid tumor (DT) is a rare benign neoplasm rising from muscle aponeurosis, having been associated mostly with trauma or pregnancy. DT has an infiltrative and locally aggressive growth pattern and usually does not metastasize. However, it has a high recurrence and complication rate. When they occur in pregnancy, are all pregnancies and deliveries taken as individual case for optimal management by the physicians and midwifes, who need to be cautious in finding the optimal delivery mode for patients, which depends on tumor size, location, behavior and past history. Study Objectives: We present a case report of a large desmoid tumor of the anterior abdominal wall in a 29-year-old woman in pregnancy, presenting a delivery problem, which resolved in surgical management. Moreover, we are bringing a systematic review of the literature to provide an overview on pathomechanism, symptoms, diagnostics and treatment management of the pregnant women affected by DT. Results: The authors report a case of pregnant women who underwent systemic oncological treatment for abdominal wall desmoid tumor and have been pregnant afterwards. The observational conservative management was chosen with an elective cesarean section at the 38+4 pregnancy week with uncomplicated postpartum follow-up. Conclusion: Pregnancy-associated desmoid tumors are very rare and optimal management of this tumor is not well established, despite some guidelines for non-pregnant patients. The authors reviewed the literature focusing on the actual modern management of desmoid tumors at all, including patients during the pregnancy, as well.

Keywords

benign neoplasm; desmoid tumors; chemotherapy; high-risk pregnancy; delivery; uncommon complications; abdominal discomfort; management

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

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