Version 1
: Received: 2 October 2023 / Approved: 3 October 2023 / Online: 3 October 2023 (04:46:41 CEST)
Version 2
: Received: 18 February 2024 / Approved: 21 February 2024 / Online: 21 February 2024 (04:26:18 CET)
Tsiatsiou, P.; Kouirouxis, K.; Tsaireli, V.; Lanta, A.; Kassomenaki, A.; Papaioannou, M.; Protonotariou, E.; Skoura, L. Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves. Curr. Issues Mol. Biol.2024, 46, 3975-3989.
Tsiatsiou, P.; Kouirouxis, K.; Tsaireli, V.; Lanta, A.; Kassomenaki, A.; Papaioannou, M.; Protonotariou, E.; Skoura, L. Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves. Curr. Issues Mol. Biol. 2024, 46, 3975-3989.
Tsiatsiou, P.; Kouirouxis, K.; Tsaireli, V.; Lanta, A.; Kassomenaki, A.; Papaioannou, M.; Protonotariou, E.; Skoura, L. Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves. Curr. Issues Mol. Biol.2024, 46, 3975-3989.
Tsiatsiou, P.; Kouirouxis, K.; Tsaireli, V.; Lanta, A.; Kassomenaki, A.; Papaioannou, M.; Protonotariou, E.; Skoura, L. Angiopoietins as Predictor Indexes in COVID-19 Patients in Delta and Omicron Waves. Curr. Issues Mol. Biol. 2024, 46, 3975-3989.
Abstract
The study aimed to explore the correlation among Angiopoietin-1, (Ang-1) and Angiopoietin-2, (Ang-2) concentrations and the Angiopoietin-2/Angiopoietin-1 ratio, (Ang-2/Ang-1) with clinical outcomes, potentially serving as disease severity and survival biomarkers. A study at AHEPA University Hospital involved 90 COVID-19 adult patients, with 30 hospitalized in intensive care and 30 in ward units and 30 asymptomatic non-hospitalized individuals as controls. Estimated endothelial dysfunction markers related to angiogenesis were measured, and statistical analysis was performed using IBM SPSS Statistics software, version 29. There was a statistically significant difference only between outpatient and hospitalized patients (non-ICU -ICU groups) for the Ang-1 and Ang-2 indexes. The Ang-2/Ang-1 ratio has differed significantly among all individual patient groups. A ROC analysis was conducted to find an optimal threshold for distinguishing (outpatients – non-ICU) and (non-ICU –ICU) groups. It was based on Youden's Index and was 0.1122 and 0.3825, respectively. The Ang-1, Ang-2 levels, and Ang-2/Ang-1 ratio were analysed as indicators for severity in COVID-19 patients. The Ang-2/Ang-1 ratio demonstrated more excellent prognostic and diagnostic utility than individual biomarker levels. Monitoring the Ang-2/Ang-1 ratio can identify COVID-19 patients at risk and assist clinicians in tailoring treatment strategies for improved outcomes.
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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