Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Neutrophil to Lymphocyte Ratio as a Prognostic Marker in Amyotrophic Lateral Sclerosis

Camille Cotet
,
Hugo Alarcan
,
Olivier Herault
ORCID logo ,
Philippe Corcia
,
Patrick Vourc'h
,
Christian R Andres
,
Hélène Blasco
,
Charlotte Veyrat-Durebex
* ORCID logo
Version 1 : Received: 2 October 2023 / Approved: 2 October 2023 / Online: 3 October 2023 (05:55:51 CEST)

A peer-reviewed article of this Preprint also exists.

Cotet, C.; Alarcan, H.; Hérault, O.; Corcia, P.; Vourc’h, P.; Andres, C.R.; Blasco, H.; Veyrat-Durebex, C. Neutrophil to Lymphocyte Ratio as a Prognostic Marker in Amyotrophic Lateral Sclerosis. Biomolecules 2023, 13, 1689. Cotet, C.; Alarcan, H.; Hérault, O.; Corcia, P.; Vourc’h, P.; Andres, C.R.; Blasco, H.; Veyrat-Durebex, C. Neutrophil to Lymphocyte Ratio as a Prognostic Marker in Amyotrophic Lateral Sclerosis. Biomolecules 2023, 13, 1689.

Abstract

Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative motor neuron disease and remains misunderstood with difficult diagnosis and prognosis. The implication of the immune system is recognized in ALS pathophysiology, hence the interest in leucocytes count as lymphocytes and neutrophils. The neutrophil to lymphocyte ratio (NLR) has recently been used as a prognosis factor to assess the progression of ALS. Thus, the aim of this study was to analyze the evolution of the NLR during disease evolution in a French cohort of ALS patients and its relation with survival. Clinical parameters and NLR were collected in ALS patients followed at the University Hospital of Tours (France). ALS patients were subdivided into three groups in regard to their NLR value at inclusion: group 1 (NLR < 2); group 2 (NLR: 2-3); group 3 (NLR > 3). Comparison of qualitative and quantitative clinical and biological variables between NLR groups was performed. Then Cox-regressions were carried out to determine the association of NLR with survival. We observed a significant correlation of NLR with ALSFRS-r score (p<0.0001) and with vital forced capacity (p=0.0004) at inclusion. We observed that increased NLR at diagnosis is associated with decreased ALS patients’ survival.

Keywords

Amyotrophic lateral sclerosis; neutrophils; lymphocytes; NLR; survival; prognosis

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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