Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo

Ester Lopes De Melo; Bruno Augusto Machado Tavares; Abrahão Victor Tavares de Lima Teixeira dos Santos; Adriana Maciel Ferreira; Helison de Oliveira Carvalho; Andres Navarrete Castro; Arlindo César Matias Pereira; Luiz Fernando Moreira; Jose Carlos Tavares Carvalho

doi:10.20944/preprints202310.0051.v1

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preprints.org > medicine and pharmacology > medicine and pharmacology > doi: 10.20944/preprints202310.0051.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo

Ester Lopes De Melo

Bruno Augusto Machado Tavares

Abrahão Victor Tavares de Lima Teixeira dos Santos

Adriana Maciel Ferreira

^* ,

Helison de Oliveira Carvalho

Andres Navarrete Castro

Arlindo César Matias Pereira

Luiz Fernando Moreira

Jose Carlos Tavares Carvalho

Version 1 : Received: 30 September 2023 / Approved: 2 October 2023 / Online: 2 October 2023 (11:01:58 CEST)

How to cite: De Melo, E.L.; Tavares, B.A.M.; Santos, A.V.T.D.L.T.D.; Ferreira, A.M.; Carvalho, H.D.O.; Castro, A.N.; Pereira, A.C.M.; Moreira, L.F.; Carvalho, J.C.T. Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo. Preprints 2023, 2023100051. https://doi.org/10.20944/preprints202310.0051.v1 De Melo, E.L.; Tavares, B.A.M.; Santos, A.V.T.D.L.T.D.; Ferreira, A.M.; Carvalho, H.D.O.; Castro, A.N.; Pereira, A.C.M.; Moreira, L.F.; Carvalho, J.C.T. Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo. Preprints 2023, 2023100051. https://doi.org/10.20944/preprints202310.0051.v1

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MDPI and ACS Style

De Melo, E.L.; Tavares, B.A.M.; Santos, A.V.T.D.L.T.D.; Ferreira, A.M.; Carvalho, H.D.O.; Castro, A.N.; Pereira, A.C.M.; Moreira, L.F.; Carvalho, J.C.T. Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo. Preprints 2023, 2023100051. https://doi.org/10.20944/preprints202310.0051.v1

APA Style

De Melo, E.L., Tavares, B.A.M., Santos, A.V.T.D.L.T.D., Ferreira, A.M., Carvalho, H.D.O., Castro, A.N., Pereira, A.C.M., Moreira, L.F., & Carvalho, J.C.T. (2023). Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo. Preprints. https://doi.org/10.20944/preprints202310.0051.v1

Chicago/Turabian Style

De Melo, E.L., Luiz Fernando Moreira and Jose Carlos Tavares Carvalho. 2023 "Inhibition of angiogenesis by the nutraceutical Terasen® in the chorioallantoic membrane from chicken embryo" Preprints. https://doi.org/10.20944/preprints202310.0051.v1

Abstract

Angiogenesis is a process whereby new blood vessels are born from preexistent ones, which has a role in transporting oxygen and nutrients. On the other hand, inhibiting this process is a strategy used to treat some diseases, including cancers, diabetic retinopathy, and rheumatoid arthritis. This study investigates the effect of a new nutraceutical (Terasen®) on angiogenesis. Terasen® is made from a standardized extract of Euterpe oleraceae (Açaí), Myrciaria dubia (Camu-Camu), and purified oil of Bixa orellana (Annatto) and Astrocaryum aculeatum (Tucumã). The in vivo angiogenesis model used was the chorioallantoic membrane (CAM) from chicken embryos. The embryos were divided into seven groups: a vehicle control treated with ethanol solution (ETH), a naïve control treated only with saline solution (SOR), a positive control treated with dexamethasone (DEX), and four groups treated with Terasen® at different concentrations (0.5, 1, 2, and 3 mg/ml). The parameters assessed were the vessels’ area, length, and amount. The results show a statistically significant and concentration-dependent inhibition of angiogenesis caused by Terasen®. Our results suggest the nutraceutical has a high antiangiogenesis potential, possibly due to its bioactive compounds, including anthocyanins, quercetin, and tocotrienols.

Keywords

angiogenesis; nutraceuticals; chorioallantoic membrane; anthocyanins; tocotrienols.

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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