Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Sleep breathing dynamics in children with unilateral cleft lip and palate: A prospective comparative study

Version 1 : Received: 30 September 2023 / Approved: 30 September 2023 / Online: 2 October 2023 (11:14:14 CEST)

A peer-reviewed article of this Preprint also exists.

Nemoto, N.; Kawanabe, H.; Fukui, K.; Oyama, A.; Okamoto, T.; Shimamura, K. Research on Sleep Dynamics in Cleft Lip and Palate Patients Using Simple Sleep Testing. J. Clin. Med. 2023, 12, 7254. Nemoto, N.; Kawanabe, H.; Fukui, K.; Oyama, A.; Okamoto, T.; Shimamura, K. Research on Sleep Dynamics in Cleft Lip and Palate Patients Using Simple Sleep Testing. J. Clin. Med. 2023, 12, 7254.

Abstract

Sleep-disordered breathing affects the growth and development, mental aspect, and learning ability of affected children. Postoperative scarring causes anteroposterior and vertical develop-mental disorders of the maxilla. Obstructive apnea is likely to occur due to the influence on the maxillofacial and airway morphology. In this study, we investigated the sleep-respiratory dynamics of school-aged children with unilateral cleft lip and palate by performing a simple over-night sleep study, maxillofacial morphology and airway analysis using lateral cranial radiographs, and model analysis. Children with unilateral cleft lip and palate showed a significantly higher respiratory event index (REI) than normal children; the maxilla was located in the posterior position in terms of maxillofacial morphology, and airway morphology showed narrow values for all distance measurement items. Moreover, the width and length of the dental arch and the width of the alveolar base arch were significantly smaller. Furthermore, there was a negative correlation between REI and SNA, ANB, REI, and alveolar base arch width. Children with unilateral cleft lip and palate are more likely than normal children to develop sleep-disordered breathing due to in-creased airway resistance caused by undergrowth of the maxilla and narrowing of the upper airway and oral volume.

Keywords

Cleft palate; Apnea Hypopnea Index; out-of-center sleep testing (OCST); respiratory event index (REI)

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

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