Mollaoğlu, M.C.; Karabacak, U.; Bostancı, M.E.; Seven, T.E.; Karadayı, K. Is Extereme Cytoreductive Surgery Beneficial To Survival In Malignant Peritoneal Mesothelioma? Acta Chirurgica Belgica 2024, 1–12, doi:10.1080/00015458.2024.2301806.
Mollaoğlu, M.C.; Karabacak, U.; Bostancı, M.E.; Seven, T.E.; Karadayı, K. Is Extereme Cytoreductive Surgery Beneficial To Survival In Malignant Peritoneal Mesothelioma? Acta Chirurgica Belgica 2024, 1–12, doi:10.1080/00015458.2024.2301806.
Mollaoğlu, M.C.; Karabacak, U.; Bostancı, M.E.; Seven, T.E.; Karadayı, K. Is Extereme Cytoreductive Surgery Beneficial To Survival In Malignant Peritoneal Mesothelioma? Acta Chirurgica Belgica 2024, 1–12, doi:10.1080/00015458.2024.2301806.
Mollaoğlu, M.C.; Karabacak, U.; Bostancı, M.E.; Seven, T.E.; Karadayı, K. Is Extereme Cytoreductive Surgery Beneficial To Survival In Malignant Peritoneal Mesothelioma? Acta Chirurgica Belgica 2024, 1–12, doi:10.1080/00015458.2024.2301806.
Abstract
Extreme cytoreductive surgery (eCRS) may sometimes be required to achieve complete cytoreduction, which is one of the most important prognostic factors. This study investigated the impact of eCRS on survival and peri-postoperative outcomes. Malignant peritoneal mesothelioma (MPM) patients who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) were retrospectively examined. Patients who underwent CRS-HIPEC were divided into eCRS and less extensive CRS (leCRS) groups. Resection of ≥5 organs or ≥3 small bowel anastomoses was defined as eCRS. Survival and perioperative outcomes of both groups were compared.In the study including 31 patients, eCRS-HIPEC was used in 15 patients. Complete cytore-duction (CC score 0/1) was achieved in all 31 patients. Compared with LeCRS, mean length of stay, length of stay in the intensive care unit, mean peritoneal cancer index (PCI), and intraoperative blood loss were higher in the eCRS group. Additionally, the risk of developing complications was observed to be more frequent and the duration of surgery was longer. Rates of serious complications and morbidity were similar in patients undergoing eCRS compared with leCRS. In patients with high PCI and multiple organ involvement, complete cytoreduction can be achieved by performing eCRS and equivalent survival results can be achieved with low PCI..
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