Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Scattering of Attosecond Laser Pulses on a DNA Molecule During Its Nicking and Bending

Version 1 : Received: 27 September 2023 / Approved: 28 September 2023 / Online: 29 September 2023 (04:55:17 CEST)

A peer-reviewed article of this Preprint also exists.

Makarov, D.; Kharlamova, A. Scattering of Attosecond Laser Pulses on a DNA Molecule during Its Nicking and Bending. Int. J. Mol. Sci. 2023, 24, 15574. Makarov, D.; Kharlamova, A. Scattering of Attosecond Laser Pulses on a DNA Molecule during Its Nicking and Bending. Int. J. Mol. Sci. 2023, 24, 15574.

Abstract

It is well known that X-ray crystallography is based on X-ray diffraction (XRD) by atoms and molecules. The diffraction pattern arises as a result of scattering of incident radiation, which makes it possible to determine the structure of the scattering substance. With the advent of ultrashort radiation sources, the theory and interpretation of X-ray diffraction analysis remained the same. This work shows that when an attosecond laser pulse is scattered on a DNA molecule, including during its nicking and bending, the pulse duration is an important characteristic of the scattering. In this case, the diffraction pattern changes significantly compared to the previously known scattering theory. The results obtained must be used in XRD theory to study DNA structures, their mutations and damage, since the previously known theory can produce large errors and, therefore, the DNA structure can be “deciphered” incorrectly.

Keywords

X-ray; DNA; X-ray diffraction; attosecond pulse; USP; Nick(DNA); bending DNA.

Subject

Physical Sciences, Biophysics

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