Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Antidiabetic Therapy during Pregnancy: The Prescription Pattern in Italy

Anna Locatelli
ORCID logo ,
Sara Ornaghi
* ORCID logo ,
Alessandra Terzaghi
,
Valeria Belleudi
ORCID logo ,
Filomena Fortinguerra
ORCID logo ,
Francesca Romana Poggi
,
Serena Perna
,
Francesco Trotta
ORCID logo
Version 1 : Received: 22 September 2023 / Approved: 25 September 2023 / Online: 25 September 2023 (09:27:25 CEST)

A peer-reviewed article of this Preprint also exists.

Locatelli, A.; Ornaghi, S.; Terzaghi, A.; Belleudi, V.; Fortinguerra, F.; Poggi, F.R.; Perna, S.; Trotta, F.; MoM-Net Group. Antidiabetic Therapy during Pregnancy: The Prescription Pattern in Italy. Int. J. Environ. Res. Public Health 2023, 20, 7139. Locatelli, A.; Ornaghi, S.; Terzaghi, A.; Belleudi, V.; Fortinguerra, F.; Poggi, F.R.; Perna, S.; Trotta, F.; MoM-Net Group. Antidiabetic Therapy during Pregnancy: The Prescription Pattern in Italy. Int. J. Environ. Res. Public Health 2023, 20, 7139.

Abstract

Pregestational and gestational diabetes mellitus are relevant complications of pregnancy and antidiabetic drugs are prescribed to obtain glycemic control and improve perinatal outcomes. The objective of this study was to highlight the prescription pattern of antidiabetics before, during and after pregnancy in Italy and to evaluate its appropriateness. A multi-database cross sectional population study using a Common Data Model was performed. In a cohort of about 450,000 women, the prescribing profile of antidiabetics seemed to be in line with the Italian standards for the treatment of GDM which currently do not recommend the use of oral antidiabetics and non-insulin injection, even if a small share of new users (up to 3.8% in the third trimester) used oral antidiabetics. A substantial variability in the prescription pattern was observed among the Italian regions considered: the highest increase was registered in Tuscany (4.2%), Umbria (3.5%) and Emilia-Romagna (2.6%) while the lowest in Lombardy (1.5%), Veneto (1.7%) and Apulia (1.7%). Analysing the prevalence of use of antidiabetics between foreign women we observed that the consumption during pregnancy was higher than Italians (second trimester: 1,8% vs 0,9%, third trimester: 3,6% vs 1,8%).

Keywords

Gestational Diabetes Mellitus; pregnancy; antidiabetic drugs; prescription pattern

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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