Version 1
: Received: 21 September 2023 / Approved: 22 September 2023 / Online: 22 September 2023 (10:07:13 CEST)
How to cite:
Hamed, A.; Abdel-Razek, A.S.; Abdelwahab, A.B.; El Taweel, A.; Gaballah, M.; Sewald, N.; Shaaban, M. Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies. Preprints2023, 2023091552. https://doi.org/10.20944/preprints202309.1552.v1
Hamed, A.; Abdel-Razek, A.S.; Abdelwahab, A.B.; El Taweel, A.; Gaballah, M.; Sewald, N.; Shaaban, M. Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies. Preprints 2023, 2023091552. https://doi.org/10.20944/preprints202309.1552.v1
Hamed, A.; Abdel-Razek, A.S.; Abdelwahab, A.B.; El Taweel, A.; Gaballah, M.; Sewald, N.; Shaaban, M. Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies. Preprints2023, 2023091552. https://doi.org/10.20944/preprints202309.1552.v1
APA Style
Hamed, A., Abdel-Razek, A.S., Abdelwahab, A.B., El Taweel, A., Gaballah, M., Sewald, N., & Shaaban, M. (2023). Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies. Preprints. https://doi.org/10.20944/preprints202309.1552.v1
Chicago/Turabian Style
Hamed, A., Norbert Sewald and Mohamed Shaaban. 2023 "Diverse Bioactive Secondary Metabolites from Aspergillus terreus: Antimicrobial, Anticancer and Anti- SARS-CoV-2 Activity Studies" Preprints. https://doi.org/10.20944/preprints202309.1552.v1
Abstract
The recently reported microbial natural product N-benzoyl-tryptophane (1) along with twenty-two diverse known bioactive compounds were isolated from the marine Aspergillus terreus LGO13 after its re-cultivation using liquid culture fermentation. Structures of the isolated compounds were established on the basis of HR-ESIMS 1D/2D NMR spectroscopy, and comparison with literature data. The antimicrobial, cytotoxicity, and antiviral activities of the microbial extract and the obtained compounds were investigated using a set of microorganisms, cervix carcinoma KB-3-1, non-small cell lung cancer (NSCLC) A549, and coronavirus (SARS-CoV-2), respectively. Molecular docking (MD) simulation was employed to explore the theoretical targets of the isolated metabolites as anti-SARS-CoV-2 agents. Chaetominine (2) seemed to be a potential candidate against papain-like protease (PLpro), one of the viral proteins being aimed by recent research as a possible target of anti-covid agents. Inspired by the MD results, we accordingly assessed the antiviral efficacy of chaetominine (2), fumitremorgin C (6), and azaspirofuran A (9) against SARS-CoV-2. Fumitremorgin C (6) showed a high selectivity index (SI = 20.3), while chaetominine (2) and azaspirofuran A (9) showed moderate selectivity index (SI = 6.6 and 3.2, respectively). These results showed a promising antiviral activity of Fumitremorgin C against SARS-CoV-2 virus.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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