Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project

Oscar Nieves Paniagua; David Ortiz de Zárate; Elena Aznar; Isabel Caballos; Eva Garrido; Ramón Martínez Mañez; Fabian Dortu; Damien Bernier; Beatriz Mengual-Chuliá; F. Xavier López-Labrador; Jens J. Sloth; Katrin Löschner; Lene Duedahl-Olesen; Natalia Prado; Martín Hervello; Armando Menéndez; Rainer Gransee; Thomas Klotzbuecher; Maria Clara Henriques Baptista Gonçalves; Fahimeh Zare; Ana Fuentes López; Isabel Fernández-Segovia; José M. Barat; Jaime Salcedo; Sara Recuero; Santiago Simón; Ana Fernández Blanco; Sergio Peransi; Maribel Gómez-Gómez; Amadeu Griol

doi:10.20944/preprints202309.1514.v1

A peer-reviewed article of this Preprint also exists.

Nieves, O.; Ortiz de Zárate, D.; Aznar, E.; Caballos, I.; Garrido, E.; Martínez-Máñez, R.; Dortu, F.; Bernier, D.; Mengual-Chuliá, B.; López-Labrador, F.X.; Sloth, J.J.; Loeschner, K.; Duedahl-Olesen, L.; Prado, N.; Hervello, M.; Menéndez, A.; Gransee, R.; Klotzbuecher, T.; Gonçalves, M.C.; Zare, F.; Fuentes López, A.; Fernández Segovia, I.; Baviera, J.M.B.; Salcedo, J.; Recuero, S.; Simón, S.; Fernández Blanco, A.; Peransi, S.; Gómez-Gómez, M.; Griol, A. Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project. Sensors 2023, 23, 8548. Nieves, O.; Ortiz de Zárate, D.; Aznar, E.; Caballos, I.; Garrido, E.; Martínez-Máñez, R.; Dortu, F.; Bernier, D.; Mengual-Chuliá, B.; López-Labrador, F.X.; Sloth, J.J.; Loeschner, K.; Duedahl-Olesen, L.; Prado, N.; Hervello, M.; Menéndez, A.; Gransee, R.; Klotzbuecher, T.; Gonçalves, M.C.; Zare, F.; Fuentes López, A.; Fernández Segovia, I.; Baviera, J.M.B.; Salcedo, J.; Recuero, S.; Simón, S.; Fernández Blanco, A.; Peransi, S.; Gómez-Gómez, M.; Griol, A. Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project. Sensors 2023, 23, 8548.

Abstract

This paper presents the concept of a novel adaptable sensing solution currently being developed under the EU Commission founded PHOTONGATE project. This concept will allow to quantify multiple analytes of the same or different nature (chemicals, metals, bacteria, etc.) in a single test with levels of sensitivity and selectivity at/or over those offered by current solutions. PHOTONGATE relies on two core technologies: a bio-chemical technology (molecular gates) which will confer the specificity and, therefore, the capability to be adaptable to the analyte of interest, and which combined with porous substrates will increase the sensitivity, and a photonic technology based on Local Surface Plasmonic Resonance (LSPR) structures serves as transducer for light interaction. Both technologies are in the micron range, facilitating the integration of multiple sensors within a small area (mm²). The concept will be developed for its application in health diagnosis and food safety sectors. It is thought as an easy-to-use modular concept, which will consist of the sensing module, mainly of a microfluidics cartridge that will house the photonic sensor, and a platform for fluidic handling, optical interrogation, and signal processing. The platform will include a new optical concept, fully Europe Union Made, avoiding optical fibers and expensive optical components.

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Development of Photonic Multi-Sensing Systems Based on Molecular Gates Biorecognition and Plasmonic Sensors: The PHOTONGATE Project

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