Seebacher, W.; Hoffelner, M.; Belaj, F.; Pirker, T.; Alajlani, M.; Bauer, R.; Pferschy-Wenzig, E.-M.; Saf, R.; Weis, R. Formation of 5-Aminomethyl-2,3-Dihydropyridine-4(1H)-Ones from 4-Amino-Tetrahydropyridinylidene Salts. Molecules2023, 28, 6869.
Seebacher, W.; Hoffelner, M.; Belaj, F.; Pirker, T.; Alajlani, M.; Bauer, R.; Pferschy-Wenzig, E.-M.; Saf, R.; Weis, R. Formation of 5-Aminomethyl-2,3-Dihydropyridine-4(1H)-Ones from 4-Amino-Tetrahydropyridinylidene Salts. Molecules 2023, 28, 6869.
Seebacher, W.; Hoffelner, M.; Belaj, F.; Pirker, T.; Alajlani, M.; Bauer, R.; Pferschy-Wenzig, E.-M.; Saf, R.; Weis, R. Formation of 5-Aminomethyl-2,3-Dihydropyridine-4(1H)-Ones from 4-Amino-Tetrahydropyridinylidene Salts. Molecules2023, 28, 6869.
Seebacher, W.; Hoffelner, M.; Belaj, F.; Pirker, T.; Alajlani, M.; Bauer, R.; Pferschy-Wenzig, E.-M.; Saf, R.; Weis, R. Formation of 5-Aminomethyl-2,3-Dihydropyridine-4(1H)-Ones from 4-Amino-Tetrahydropyridinylidene Salts. Molecules 2023, 28, 6869.
Abstract
Various 4-aminotetrahydropyridinylidene salts were treated with aldehydes in alkaline medium. Their conversion to 5-substituted -hydroxyketones in a one-step reaction succeeded only with an aliphatic aldehyde. Instead, aromatic aldehydes gave 5-substituted -aminoketones or a single -diketone. The new compounds were characterized by spectroscopic methods and a single crystal structure analysis. Some of them showed anticancer and antibacterial properties.
Chemistry and Materials Science, Organic Chemistry
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