PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
Towards a Better Diagnosis and Treatment of Dementia: Identifying Common and Distinct Neuropathological Mechanisms in Alzheimer’s Disease and Vascular Dementia
Version 1
: Received: 19 September 2023 / Approved: 21 September 2023 / Online: 21 September 2023 (11:28:47 CEST)
How to cite:
Vollhardt, A.; Frölich, L.; Stockbauer, A.C.; Danek, A.; Schmitz, C.; Wahl, A. Towards a Better Diagnosis and Treatment of Dementia: Identifying Common and Distinct Neuropathological Mechanisms in Alzheimer’s Disease and Vascular Dementia. Preprints2023, 2023091473. https://doi.org/10.20944/preprints202309.1473.v1
Vollhardt, A.; Frölich, L.; Stockbauer, A.C.; Danek, A.; Schmitz, C.; Wahl, A. Towards a Better Diagnosis and Treatment of Dementia: Identifying Common and Distinct Neuropathological Mechanisms in Alzheimer’s Disease and Vascular Dementia. Preprints 2023, 2023091473. https://doi.org/10.20944/preprints202309.1473.v1
Vollhardt, A.; Frölich, L.; Stockbauer, A.C.; Danek, A.; Schmitz, C.; Wahl, A. Towards a Better Diagnosis and Treatment of Dementia: Identifying Common and Distinct Neuropathological Mechanisms in Alzheimer’s Disease and Vascular Dementia. Preprints2023, 2023091473. https://doi.org/10.20944/preprints202309.1473.v1
APA Style
Vollhardt, A., Frölich, L., Stockbauer, A.C., Danek, A., Schmitz, C., & Wahl, A. (2023). Towards a Better Diagnosis and Treatment of Dementia: Identifying Common and Distinct Neuropathological Mechanisms in Alzheimer’s Disease and Vascular Dementia. Preprints. https://doi.org/10.20944/preprints202309.1473.v1
Chicago/Turabian Style
Vollhardt, A., Christoph Schmitz and Anna-Sophia Wahl. 2023 "Towards a Better Diagnosis and Treatment of Dementia: Identifying Common and Distinct Neuropathological Mechanisms in Alzheimer’s Disease and Vascular Dementia" Preprints. https://doi.org/10.20944/preprints202309.1473.v1
Abstract
Alzheimer’s disease (AD) and vascular dementia (VaD) together contribute to almost 90% of all dementia cases leading to major health challenges of our time with a substantial global socioeconomic burden. While in Alzheimer’s disease, the improved understanding of Amyloid beta (Aß) mismetabolism and tau hyperphosphorylation as pathophysiological hallmarks has led to significant clinical breakthroughs, similar advances in VaD are lacking. We thus highlight here the importance of shared pathomechanisms found in AD and VaD: Endothelial damage, blood brain barrier (BBB) breakdown and hypoperfusion inducing oxidative stress, inflammation and demyelination and thus trophic uncoupling in the neurovascular unit. A dysfunctional endothelium and BBB lead to the accumulation of neurotoxic molecules and Aß through impaired clearance, which in turn leads to neurodegeneration. In this context we discuss possible neuropathological parameters, which might serve as biomarkers and thus improve diagnostic accuracy or reveal targets for novel therapeutic strategies for both forms of dementia.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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