Review
Version 1
Preserved in Portico This version is not peer-reviewed
The Use of Microfluidic Systems for Nanoparticle Production
Version 1
: Received: 18 September 2023 / Approved: 18 September 2023 / Online: 21 September 2023 (05:03:57 CEST)
A peer-reviewed article of this Preprint also exists.
Bezelya, A.; Küçüktürkmen, B.; Bozkır, A. Microfluidic Devices for Precision Nanoparticle Production. Micro 2023, 3, 822-866. Bezelya, A.; Küçüktürkmen, B.; Bozkır, A. Microfluidic Devices for Precision Nanoparticle Production. Micro 2023, 3, 822-866.
Abstract
In recent years, the field of drug delivery has seen a significant shift towards the exploration and utilisation of nanoparticles (NPs) as versatile carriers for therapeutic agents. With its ability to provide exact control over NPs' characteristics, microfluidics has emerged as a potent platform for the efficient and controlled synthesis of NPs. Microfluidic devices designed for precise fluid ma-nipulation at the micro-scale offer a unique platform for tailoring NP properties, enabling en-hanced control over NP properties such as size, morphology and size distribution while ensuring high batch-to-batch reproducibility. Microfluidics can be used to produce liposomes, solid lipid nanoparticles, polymer-based NPs and lipid-polymer hybrid NPs, as well as a variety of inorganic NPs such as silica, metal, metal oxide, quantum dots and carbon-based NPs, offering precise control over composition and surface properties. Its unique precision in tailoring NP properties holds great promise for advancing NP-based drug delivery systems in both clinical and industrial set-tings. Although challenges with large-scale production still remain, microfluidics offers a trans-formative approach to NP synthesis. In this review, starting from the historical development of microfluidic systems, the materials used to create the systems, microfabrication methods and system components will be discussed in order to provide the reader with an overview of micro-fluidic systems. In the following, studies on the fabrication of nanoparticles such as lipid NPs, polymeric NPs and inorganic NPs in microfluidic devices are included.
Keywords
microfluidic system; nanoparticle; lipid-based nanoparticles; polymeric nanoparticles
Subject
Medicine and Pharmacology, Pharmacy
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
